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A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
DC Field | Value | Language |
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dc.contributor.author | Jang, Joon Hwan | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Jang, Dong Pyo | - |
dc.contributor.author | Moon, Won-Jin | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Ha, Tae Hyun | - |
dc.contributor.author | Chung, Eun Chul | - |
dc.contributor.author | Kim, In Young | - |
dc.contributor.author | Kim, Sun I | - |
dc.date.accessioned | 2010-01-12T02:12:17Z | - |
dc.date.available | 2010-01-12T02:12:17Z | - |
dc.date.issued | 2006-07-04 | - |
dc.identifier.citation | Am J Psychiatry. 2006 Jul;163(7):1202-7. | en |
dc.identifier.issn | 0002-953X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816225 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29582 | - |
dc.description.abstract | OBJECTIVE: Reductions in the level of N-acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N-acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N-acetylaspartate levels (obtained from ratios of N-acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by (1)H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N-acetylaspartate concentrations in regions of interest and clinical measures were also assessed. RESULTS: Drug-naive OCD patients exhibited significantly lower N-acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N-acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. CONCLUSIONS: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible. | en |
dc.language.iso | en | en |
dc.publisher | American Psychiatric Publishing | en |
dc.subject | Adult | en |
dc.subject | Aspartic Acid/*analogs & derivatives/metabolism | en |
dc.subject | Brain/drug effects/*metabolism | en |
dc.subject | Brain Chemistry/drug effects | en |
dc.subject | Choline/metabolism | en |
dc.subject | Citalopram/*pharmacokinetics/*therapeutic use | en |
dc.subject | Creatine/metabolism | en |
dc.subject | Female | en |
dc.subject | Frontal Lobe/drug effects/metabolism | en |
dc.subject | Gyrus Cinguli/drug effects/metabolism | en |
dc.subject | Humans | en |
dc.subject | Longitudinal Studies | en |
dc.subject | Male | en |
dc.subject | Obsessive-Compulsive Disorder/diagnosis/*drug therapy/metabolism | en |
dc.subject | Personality Inventory | en |
dc.subject | Prefrontal Cortex/drug effects/metabolism | en |
dc.subject | Protons | en |
dc.subject | Psychiatric Status Rating Scales | en |
dc.subject | Serotonin Uptake Inhibitors/*pharmacokinetics/*therapeutic use | en |
dc.subject | Magnetic Resonance Spectroscopy | - |
dc.title | A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 장준환 | - |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.contributor.AlternativeAuthor | 장동표 | - |
dc.contributor.AlternativeAuthor | 문원진 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 하태현 | - |
dc.contributor.AlternativeAuthor | 정은철 | - |
dc.contributor.AlternativeAuthor | 김인영 | - |
dc.contributor.AlternativeAuthor | 김선이 | - |
dc.identifier.doi | 10.1176/appi.ajp.163.7.1202 | - |
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