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A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder

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dc.contributor.authorJang, Joon Hwan-
dc.contributor.authorKwon, Jun Soo-
dc.contributor.authorJang, Dong Pyo-
dc.contributor.authorMoon, Won-Jin-
dc.contributor.authorLee, Jong-Min-
dc.contributor.authorHa, Tae Hyun-
dc.contributor.authorChung, Eun Chul-
dc.contributor.authorKim, In Young-
dc.contributor.authorKim, Sun I-
dc.date.accessioned2010-01-12T02:12:17Z-
dc.date.available2010-01-12T02:12:17Z-
dc.date.issued2006-07-04-
dc.identifier.citationAm J Psychiatry. 2006 Jul;163(7):1202-7.en
dc.identifier.issn0002-953X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816225-
dc.identifier.urihttps://hdl.handle.net/10371/29582-
dc.description.abstractOBJECTIVE: Reductions in the level of N-acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N-acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N-acetylaspartate levels (obtained from ratios of N-acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by (1)H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N-acetylaspartate concentrations in regions of interest and clinical measures were also assessed. RESULTS: Drug-naive OCD patients exhibited significantly lower N-acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N-acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. CONCLUSIONS: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible.en
dc.language.isoenen
dc.publisherAmerican Psychiatric Publishingen
dc.subjectAdulten
dc.subjectAspartic Acid/*analogs & derivatives/metabolismen
dc.subjectBrain/drug effects/*metabolismen
dc.subjectBrain Chemistry/drug effectsen
dc.subjectCholine/metabolismen
dc.subjectCitalopram/*pharmacokinetics/*therapeutic useen
dc.subjectCreatine/metabolismen
dc.subjectFemaleen
dc.subjectFrontal Lobe/drug effects/metabolismen
dc.subjectGyrus Cinguli/drug effects/metabolismen
dc.subjectHumansen
dc.subjectLongitudinal Studiesen
dc.subjectMaleen
dc.subjectObsessive-Compulsive Disorder/diagnosis/*drug therapy/metabolismen
dc.subjectPersonality Inventoryen
dc.subjectPrefrontal Cortex/drug effects/metabolismen
dc.subjectProtonsen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectSerotonin Uptake Inhibitors/*pharmacokinetics/*therapeutic useen
dc.subjectMagnetic Resonance Spectroscopy-
dc.titleA proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorderen
dc.typeArticleen
dc.contributor.AlternativeAuthor장준환-
dc.contributor.AlternativeAuthor권준수-
dc.contributor.AlternativeAuthor장동표-
dc.contributor.AlternativeAuthor문원진-
dc.contributor.AlternativeAuthor이종민-
dc.contributor.AlternativeAuthor하태현-
dc.contributor.AlternativeAuthor정은철-
dc.contributor.AlternativeAuthor김인영-
dc.contributor.AlternativeAuthor김선이-
dc.identifier.doi10.1176/appi.ajp.163.7.1202-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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