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Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study

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dc.contributor.authorLee, Dong Young-
dc.contributor.authorChoo, Il Han-
dc.contributor.authorJhoo, Jin Hyeong-
dc.contributor.authorKim, Ki Woong-
dc.contributor.authorYoun, Jong Choul-
dc.contributor.authorLee, Dong Su-
dc.contributor.authorKang, Eun Joo-
dc.contributor.authorLee, Jae Sung-
dc.contributor.authorKang, Won Jun-
dc.contributor.authorWoo, Jong In-
dc.date.accessioned2010-01-12T05:38:01Z-
dc.date.available2010-01-12T05:38:01Z-
dc.date.issued2006-07-04-
dc.identifier.citationAm J Geriatr Psychiatry. 2006 Jul;14(7):625-8.en
dc.identifier.issn1064-7481 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816017-
dc.identifier.urihttps://hdl.handle.net/10371/29693-
dc.description.abstractOBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.en
dc.language.isoen-
dc.publisherAmerican Association for Geriatric Psychiatryen
dc.subjectAgeden
dc.subjectAlzheimer Disease/*physiopathology/*radionuclide imagingen
dc.subjectDepressive Disorder, Major/*physiopathology/*radionuclide imagingen
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/*diagnostic use/*pharmacokineticsen
dc.subjectFrontal Lobe/*metabolism/*physiopathologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subject*Positron-Emission Tomographyen
dc.subjectRadiopharmaceuticals/*diagnostic use/*pharmacokineticsen
dc.titleFrontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET studyen
dc.typeArticleen
dc.contributor.AlternativeAuthor이동영-
dc.contributor.AlternativeAuthor추일환-
dc.contributor.AlternativeAuthor주진형-
dc.contributor.AlternativeAuthor김기웅-
dc.contributor.AlternativeAuthor윤종철-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor강은주-
dc.contributor.AlternativeAuthor이재성-
dc.contributor.AlternativeAuthor우종인-
dc.identifier.doi10.1097/01.JGP.0000214541.79965.2d-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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