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Clinical features and risk factors of postsurgical gout

Cited 34 time in Web of Science Cited 42 time in Scopus
Authors
Kang, E H; Lee, E Y; Lee, Y J; Song, Y W; Lee, E B
Issue Date
2007-11-14
Publisher
BMJ Publishing Group
Citation
Ann Rheum Dis. 2008 Sep;67(9):1271-5. Epub 2007 Nov 12.
Keywords
AgedCase-Control StudiesColchicine/administration & dosageFemaleGout/blood/*etiology/pathology/prevention & controlGout Suppressants/administration & dosageHumansLower Extremity/pathologyMaleMiddle Aged*Postoperative Complications/blood/pathology/prevention & controlPostoperative PeriodPreoperative Care/methodsRecurrenceRisk FactorsUpper Extremity/pathologyUric Acid/blood
Abstract
OBJECTIVES: To investigate the clinical characteristics and risk factors of gout attacks that develop during the postsurgical period. METHODS: We enrolled 67 patients with gout who developed postsurgical gout and 67 controls who had histories of gout but did not develop gout attacks after surgery. Features of the postsurgical gout attacks were analysed and compared to those of presurgical gout attacks suffered by patients and controls. Demographics, medical backgrounds, laboratory data and surgical factors were compared between patients and controls in order to establish risk factors associated with postsurgical gout. RESULTS: The mean (SD) time interval to develop postsurgical gout was 4.2 (3.1) days. The attacks tended to involve lower extremity joints (65/67, 97.0%), usually the first metatarsophalangeal joint (42/67, 62.7%), and to affect more than one joint (34/67, 50.7%). The number of attacked joints was positively correlated with the total number of previously involved joints (r = 0.281, p = 0.026). The site of attacks had a preference for the previously affected sites. A history of cancer surgery (p = 0.002), elevated presurgical serum urate levels (>/=9 mg/dl; p = 0.002) and failure to administer colchicine prophylaxis (p = 0.008) were found to be risk factors for postsurgical gout. CONCLUSIONS: Postsurgical gout tends to develop within 8 days after surgery. The site and number of involved joints reflect the features of gout attacks the patient suffered before surgery. Adequate presurgical control of serum uric acid levels and/or prophylactic administration of colchicine will help prevent gout attacks during the postsurgical period.
ISSN
1468-2060 (Electronic)
Language
English
URI
http://ard.bmj.com/cgi/content/abstract/67/9/1271

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17998214

https://hdl.handle.net/10371/29712
DOI
https://doi.org/10.1136/ard.2007.078683
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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