S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Physiology (생리학교실) Journal Papers (저널논문_생리학교실)
Long-term depression of mGluR1 signaling
- Kim, Sang Jeong; Jin, Yunju; Kim, Jun; Worley, Paul F.; Linden, David J.
- Issue Date
- Cell Press
- Neuron. 2007 Jul 19;55(2):277-87.
- Animals; Calcium Signaling/physiology; Excitatory Postsynaptic Potentials/*physiology; Long-Term Synaptic Depression/*physiology; Nerve Fibers/metabolism; Patch-Clamp Techniques; Purkinje Cells/*metabolism; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate/*metabolism; Synaptic Transmission/*physiology
- Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression. Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells. Here, we show that the mGluR1-dependent slow EPSC and its coincident Ca transient were selectively and persistently depressed by repeated climbing fiber-evoked depolarization of Purkinje cells in brain slices. LTD(mGluR1) was also observed when slow synaptic current was evoked by exogenous application of a group I mGluR agonist, implying a postsynaptic expression mechanism. Ca imaging further revealed that LTD(mGluR1) was expressed as coincident attenuation of both limbs of mGluR1 signaling: the slow EPSC and PLC/IP3-mediated dendritic Ca mobilization. Thus, different patterns of neural activity can evoke LTD of either fast ionotropic or slow mGluR1-mediated synaptic signaling.
- 0896-6273 (Print)
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