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Long-term depression of mGluR1 signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Jin, Yunju | - |
dc.contributor.author | Kim, Jun | - |
dc.contributor.author | Worley, Paul F. | - |
dc.contributor.author | Linden, David J. | - |
dc.date.accessioned | 2010-01-12T06:51:19Z | - |
dc.date.available | 2010-01-12T06:51:19Z | - |
dc.date.issued | 2007-07-21 | - |
dc.identifier.citation | Neuron. 2007 Jul 19;55(2):277-87. | en |
dc.identifier.issn | 0896-6273 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17640528 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29742 | - |
dc.description.abstract | Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression. Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells. Here, we show that the mGluR1-dependent slow EPSC and its coincident Ca transient were selectively and persistently depressed by repeated climbing fiber-evoked depolarization of Purkinje cells in brain slices. LTD(mGluR1) was also observed when slow synaptic current was evoked by exogenous application of a group I mGluR agonist, implying a postsynaptic expression mechanism. Ca imaging further revealed that LTD(mGluR1) was expressed as coincident attenuation of both limbs of mGluR1 signaling: the slow EPSC and PLC/IP3-mediated dendritic Ca mobilization. Thus, different patterns of neural activity can evoke LTD of either fast ionotropic or slow mGluR1-mediated synaptic signaling. | en |
dc.language.iso | en | en |
dc.publisher | Cell Press | en |
dc.subject | Animals | en |
dc.subject | Calcium Signaling/physiology | en |
dc.subject | Excitatory Postsynaptic Potentials/*physiology | en |
dc.subject | Long-Term Synaptic Depression/*physiology | en |
dc.subject | Nerve Fibers/metabolism | en |
dc.subject | Patch-Clamp Techniques | en |
dc.subject | Purkinje Cells/*metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Receptors, Metabotropic Glutamate/*metabolism | en |
dc.subject | Synaptic Transmission/*physiology | en |
dc.title | Long-term depression of mGluR1 signaling | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 진윤주 | - |
dc.contributor.AlternativeAuthor | 김상정 | - |
dc.contributor.AlternativeAuthor | 김준 | - |
dc.identifier.doi | 10.1016/j.neuron.2007.06.035 | - |
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