Publications

Detailed Information

Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea

DC Field Value Language
dc.contributor.authorSong, Byung-Cheol-
dc.contributor.authorKim, Hong-
dc.contributor.authorKim, Sun-Hyun-
dc.contributor.authorCha, Chang-Yong-
dc.contributor.authorKook, Yoon-Hoh-
dc.contributor.authorKim, Bum-Joon-
dc.date.accessioned2010-01-13T02:14:59Z-
dc.date.available2010-01-13T02:14:59Z-
dc.date.issued2004-11-16-
dc.identifier.citationJ Med Virol. 2005 Jan;75(1):13-9.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15543574-
dc.identifier.urihttps://hdl.handle.net/10371/29814-
dc.description.abstractRelatively few genomic sequences of Korean hepatitis B virus (HBV) isolates are available. Moreover, no comparative study has been made between the full-length genomes of Korean HBV isolates and clinical status. To evaluate mutations in HBV isolates obtained from chronically infected HBV patients in terms of clinical significance, we determined the genomic sequences of HBV isolates obtained from three hepatocellular carcinoma (HCC) patients (He52, He53, and He82) and from three asymptomatic carriers (He74, He100, and He127). A comparison of sequence variations showed that the HBV isolates from the three HCC patients showed higher frequencies of mutation than the isolates from the three asymptomatic carriers. Three characteristic mutation patterns were identified in the HBV isolates from the HCC patients, which distinguished the HBV isolates from the asymptomatic carriers. First, HBV isolates from the three HCC patients both had double mutations in a core promoter (T1762/A1764) and a precore mutation (A1896). Second, although these isolates belonged to genotype C, 11 amino acids deletions in the preS1 region, specific for HBV genotype D, were detected in the isolates of two HCC patients (He52 and He82). Third, mutations (I127T/N, K130M, and V131I) at three codons in the carboxy functional region of X protein were observed in isolates from all three HCC patients. Additionally, phylogenetic analysis based on the entire HBV sequences showed that all six isolates belonged to genotype C2, as do other Korean strains.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAmino Acid Sequenceen
dc.subjectAmino Acid Substitution/geneticsen
dc.subjectCarcinoma, Hepatocellular/*virologyen
dc.subjectCarrier State/*virologyen
dc.subjectFemaleen
dc.subjectGenome, Viralen
dc.subjectGenotypeen
dc.subjectHepatitis B Surface Antigens/geneticsen
dc.subjectHepatitis B virus/*genetics/isolation & purificationen
dc.subjectHepatitis B, Chronic/*virologyen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMolecular Sequence Dataen
dc.subjectMutation, Missense/geneticsen
dc.subjectPhylogenyen
dc.subjectPoint Mutation/geneticsen
dc.subjectPromoter Regions, Genetic/geneticsen
dc.subjectProtein Precursors/geneticsen
dc.subjectSequence Deletion/geneticsen
dc.subjectTrans-Activators/geneticsen
dc.subjectBase Sequence-
dc.titleComparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor송병철-
dc.contributor.AlternativeAuthor김홍-
dc.contributor.AlternativeAuthor김선현-
dc.contributor.AlternativeAuthor차창용-
dc.contributor.AlternativeAuthor국윤호-
dc.contributor.AlternativeAuthor김범준-
dc.identifier.doi10.1002/jmv.20230-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share