Browse

Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection

DC Field Value Language
dc.contributor.authorYun, Ji-Hyun-
dc.contributor.authorKoh, Young-Sang-
dc.contributor.authorLee, Keun-Hwa-
dc.contributor.authorHyun, Jin-Won-
dc.contributor.authorChoi, Yeon-Joo-
dc.contributor.authorJang, Won-Jong-
dc.contributor.authorPark, Kyung-Hee-
dc.contributor.authorCho, Nam-Hyuk-
dc.contributor.authorSeong, Seung-Yong-
dc.contributor.authorChoi, Myung-Sik-
dc.contributor.authorKim, Ik-Sang-
dc.date.accessioned2010-01-13T02:24:38Z-
dc.date.available2010-01-13T02:24:38Z-
dc.date.issued2005-06-21-
dc.identifier.citationMicrobiol Immunol. 2005;49(6):551-7.en
dc.identifier.issn0385-5600 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15965303-
dc.identifier.urihttp://hdl.handle.net/10371/29821-
dc.description.abstractTo understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1 alpha (MIP-1 alpha ), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-gamma ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-alpha ) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectChemokines/*biosynthesis/genetics/metabolismen
dc.subjectCytokines/*biosynthesis/geneticsen
dc.subjectInterleukin-10/biosynthesisen
dc.subjectInterleukin-12/biosynthesisen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Inbred C3Hen
dc.subject*Orientia tsutsugamushien
dc.subjectScrub Typhus/etiology/genetics/*immunologyen
dc.subjectTumor Necrosis Factor-alpha/biosynthesis/geneticsen
dc.titleChemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infectionen
dc.typeArticleen
dc.contributor.AlternativeAuthor윤지현-
dc.contributor.AlternativeAuthor고영상-
dc.contributor.AlternativeAuthor이근화-
dc.contributor.AlternativeAuthor현진원-
dc.contributor.AlternativeAuthor최연주-
dc.contributor.AlternativeAuthor장원종-
dc.contributor.AlternativeAuthor박경희-
dc.contributor.AlternativeAuthor조남혁-
dc.contributor.AlternativeAuthor성승용-
dc.contributor.AlternativeAuthor최명식-
dc.contributor.AlternativeAuthor김익상-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse