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Brain white-matter hyperintensities and treatment outcome in major depressive disorder

Cited 45 time in Web of Science Cited 58 time in Scopus
Authors
Iosifescu, Dan V; Renshaw, Perry F; Lyoo, In Kyoon; Lee, Ho Kyu; Perlis, Roy H; Papakostas, George I; Nierenberg, Andrew A; Fava, Maurizio
Issue Date
2006
Publisher
Royal College of Psychiatrists
Citation
British Journal of Psychiatry,188:180-185
Keywords
Age FactorsAntidepressive Agents/therapeutic useBrain/*pathologyCardiovascular Diseases/etiology/pathologyDepressive Disorder, Major/complications/drug therapy/*pathologyHumansHypertension/etiology/pathologyMagnetic Resonance Imaging/methodsRisk FactorsSeverity of Illness IndexTreatment Outcome
Abstract
BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
ISSN
0007-1250 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16449707

https://hdl.handle.net/10371/29859
DOI
https://doi.org/10.1192/bjp.188.2.180
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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