S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Brain white-matter hyperintensities and treatment outcome in major depressive disorder
- Iosifescu, Dan V; Renshaw, Perry F; Lyoo, In Kyoon; Lee, Ho Kyu; Perlis, Roy H; Papakostas, George I; Nierenberg, Andrew A; Fava, Maurizio
- Issue Date
- Royal College of Psychiatrists
- British Journal of Psychiatry,188:180-185
- Age Factors; Antidepressive Agents/therapeutic use; Brain/*pathology; Cardiovascular Diseases/etiology/pathology; Depressive Disorder, Major/complications/drug therapy/*pathology; Humans; Hypertension/etiology/pathology; Magnetic Resonance Imaging/methods; Risk Factors; Severity of Illness Index; Treatment Outcome
- BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
- 0007-1250 (Print)
- Files in This Item: There are no files associated with this item.