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Brain white-matter hyperintensities and treatment outcome in major depressive disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Iosifescu, Dan V | - |
dc.contributor.author | Renshaw, Perry F | - |
dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Lee, Ho Kyu | - |
dc.contributor.author | Perlis, Roy H | - |
dc.contributor.author | Papakostas, George I | - |
dc.contributor.author | Nierenberg, Andrew A | - |
dc.contributor.author | Fava, Maurizio | - |
dc.date.accessioned | 2010-01-13T04:34:45Z | - |
dc.date.available | 2010-01-13T04:34:45Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | British Journal of Psychiatry,188:180-185 | en |
dc.identifier.issn | 0007-1250 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16449707 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29859 | - |
dc.description.abstract | BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression. | en |
dc.language.iso | en | en |
dc.publisher | Royal College of Psychiatrists | en |
dc.subject | Age Factors | en |
dc.subject | Antidepressive Agents/therapeutic use | en |
dc.subject | Brain/*pathology | en |
dc.subject | Cardiovascular Diseases/etiology/pathology | en |
dc.subject | Depressive Disorder, Major/complications/drug therapy/*pathology | en |
dc.subject | Humans | en |
dc.subject | Hypertension/etiology/pathology | en |
dc.subject | Magnetic Resonance Imaging/methods | en |
dc.subject | Risk Factors | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Treatment Outcome | en |
dc.title | Brain white-matter hyperintensities and treatment outcome in major depressive disorder | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 류인균 | - |
dc.contributor.AlternativeAuthor | 이호규 | - |
dc.identifier.doi | 10.1192/bjp.188.2.180 | - |
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