Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma

DC Field Value Language
dc.contributor.authorLee, Hyun Ju-
dc.contributor.authorKim, Dong-Il-
dc.contributor.authorKang, Gyeong Hoon-
dc.contributor.authorKwak, Cheol-
dc.contributor.authorKu, Ja Hyeon-
dc.contributor.authorMoon, Kyung Cul-
dc.identifier.citationUrology 2009;73:394-399en
dc.identifier.issn0090-4295 (print)-
dc.identifier.issn1527-9995 (online)-
dc.description.abstractOBJECTIVES : To evaluate the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in clear cell renal cell carcinoma (CCRCC) and to investigate its prognostic significance. ERK1/2 activation had been reported in RCC, but little is known about its prognostic significance.

METHODS : We immunohistochemically analyzed phosphorylated ERK1/2 (pERK) expression using tissue microarrays in 328 CCRCC specimens. The percentage of tumor cells showing positive staining was evaluated and classified into 4 categories: 0, 0%; 1+, 1%-10%; 2+, 11%-50%; and 3+, >50%. For statistical analysis, the cases were subdivided into pERK-low (0 and 1+) and pERK-high (2+ and 3+) expression.

RESULTS : Our study showed significantly greater expression of pERK in CCRCC than in non-neoplastic renal parenchyma. pERK-high expression was significantly associated with a low pT category (P = .046). The survival analysis showed a significant association between pERK-high expression and better progression-free survival (P = .014). Furthermore, the prognostic significance of pERK expression was quite different between small CCRCC (size ≤7 cm) and large CCRCC (size >7 cm) lesions. In small CCRCC, pERK-high expression correlated significantly with better cancer-specific survival (P = .018) and better progression-free survival (P < .001). However, no correlation was found between pERK expression and survival in large CCRCC.

CONCLUSIONS : High expression of pERK in CCRCC was associated with a low pT category and showed a longer progression-free survival, especially in small CCRCC. Although the biologic mechanism of the ERK pathway in CCRCC remains unknown, the results of this study suggest that pERK expression is a positive prognosticator for survival in those with small CCRCC.
dc.description.sponsorshipThis work was supported by grant 03-2005-004 from the Seoul National University
Hospital Research Fund.
dc.titlePhosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinomaen
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.