S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma
|dc.contributor.author||Lee, Hyun Ju||-|
|dc.contributor.author||Kang, Gyeong Hoon||-|
|dc.contributor.author||Ku, Ja Hyeon||-|
|dc.contributor.author||Moon, Kyung Cul||-|
|dc.description.abstract||OBJECTIVES : To evaluate the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in clear cell renal cell carcinoma (CCRCC) and to investigate its prognostic significance. ERK1/2 activation had been reported in RCC, but little is known about its prognostic significance.
METHODS : We immunohistochemically analyzed phosphorylated ERK1/2 (pERK) expression using tissue microarrays in 328 CCRCC specimens. The percentage of tumor cells showing positive staining was evaluated and classified into 4 categories: 0, 0%; 1+, 1%-10%; 2+, 11%-50%; and 3+, >50%. For statistical analysis, the cases were subdivided into pERK-low (0 and 1+) and pERK-high (2+ and 3+) expression.
RESULTS : Our study showed significantly greater expression of pERK in CCRCC than in non-neoplastic renal parenchyma. pERK-high expression was significantly associated with a low pT category (P = .046). The survival analysis showed a significant association between pERK-high expression and better progression-free survival (P = .014). Furthermore, the prognostic significance of pERK expression was quite different between small CCRCC (size ≤7 cm) and large CCRCC (size >7 cm) lesions. In small CCRCC, pERK-high expression correlated significantly with better cancer-specific survival (P = .018) and better progression-free survival (P < .001). However, no correlation was found between pERK expression and survival in large CCRCC.
CONCLUSIONS : High expression of pERK in CCRCC was associated with a low pT category and showed a longer progression-free survival, especially in small CCRCC. Although the biologic mechanism of the ERK pathway in CCRCC remains unknown, the results of this study suggest that pERK expression is a positive prognosticator for survival in those with small CCRCC.
|dc.description.sponsorship||This work was supported by grant 03-2005-004 from the Seoul National University
Hospital Research Fund.
|dc.title||Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma||en|
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