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근치적 전립선적출술 후 발견된 다발성 전립선암의 예후적 가치 : Prognostic Significance of Multifocal Tumor in Radical Prostatectomy
DC Field | Value | Language |
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dc.contributor.author | 정재승 | - |
dc.contributor.author | 한병규 | - |
dc.contributor.author | 정성진 | - |
dc.contributor.author | 문기혁 | - |
dc.contributor.author | 최기영 | - |
dc.contributor.author | 박동수 | - |
dc.contributor.author | 홍성규 | - |
dc.contributor.author | 변석수 | - |
dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2009-05-27T23:45:46Z | - |
dc.date.available | 2009-05-27T23:45:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Korean J Urol 2008;49:510-4 | en |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | http://www.urology.or.kr/journal/view.html?uid=9439 | - |
dc.identifier.uri | http://www.urology.or.kr | - |
dc.identifier.uri | https://hdl.handle.net/10371/3970 | - |
dc.description.abstract | Purpose: We investigate the impact of tumor multifocality on the biochemical
recurrence rate after radical prostatectomy. Materials and Methods: Data was collected from 525 patients who underwent radical prostatectomy for clinically localized prostate cancer from 2003 to 2007. We evaluated the potential associations of multifocality with various clinical and pathologic factors. The ability to predict extra-capsular extension (ECE) was tested by logistic regression models, whereas biochemical recurrence (BCR) was assessed via Kaplan-Meier analyses and Cox-hazard regression models. The BCR was defined as a level of serum prostate-specific antigen (PSA) of 0.2ng/ml or greater on consecutive evaluations. Results: Multifocality was observed to be significantly associated with the presence of a high grade Gleason pattern (p=0.014), the pT stage (p< 0.001), ECE (p=0.005) and a positive surgical margin (PSM) (p=0.019). Moreover, it was the independent predictor of ECE on multivariate logistic regression analyses (p=0.039). However, although multifocality had a significant influence on biochemical recurrence on the Kaplan-Meier analyses (log rank test, p=0.019), only the PSA level and the Gleason score were significant predictors of BCR on the multivariated Cox-hazard analyses. Conclusions: Although multifocality was associated with adverse pathologic features, it had no significant effect on biochemical recurrence on the multivariated cox-hazard analyses. | en |
dc.language.iso | ko | en |
dc.publisher | The Korean Urological Associaton = 대한비뇨기과학회 | en |
dc.subject | Prostate cancer | en |
dc.subject | Multifocality | en |
dc.subject | Recurrence | en |
dc.title | 근치적 전립선적출술 후 발견된 다발성 전립선암의 예후적 가치 | en |
dc.title.alternative | Prognostic Significance of Multifocal Tumor in Radical Prostatectomy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | Chung, Jae-Seung | - |
dc.contributor.AlternativeAuthor | Han, Byoung Kyu | - |
dc.contributor.AlternativeAuthor | Jeong, Seong-Jin | - |
dc.contributor.AlternativeAuthor | Moon, Ki Hyuck | - |
dc.contributor.AlternativeAuthor | Choe, Gheeyoung | - |
dc.contributor.AlternativeAuthor | Park, Dong Soo | - |
dc.contributor.AlternativeAuthor | Hong, Sung Kyu | - |
dc.contributor.AlternativeAuthor | Byun, Seok-Soo | - |
dc.contributor.AlternativeAuthor | Lee, Sang Eun | - |
dc.citation.journaltitle | Korean Journal of Urology = 대한비뇨기과학회지 | - |
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