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근치적 전립샘적출술을 시행한 699예의 전립샘암종에서 신경내분비 분화가 예후에 미치는 영향
The Prognostic Significance of Neuroendocrine Differentiation for Treating Prostatic Carcinoma in 699 Cases of Radical Prostatectomy

DC Field Value Language
dc.contributor.author강태훈-
dc.contributor.author신은-
dc.contributor.author김백희-
dc.contributor.author최기영-
dc.date.accessioned2009-05-28-
dc.date.available2009-05-28-
dc.date.issued2008-
dc.identifier.citationKorean J Pathol. 2008;42:381-8en
dc.identifier.issn1738-1843-
dc.identifier.urihttp://www.pathology.or.kr/04_JOURN/view.asp?jid=20080381-
dc.identifier.urihttp://www.pathology.or.kr-
dc.identifier.urihttps://hdl.handle.net/10371/3992-
dc.description.abstractBACKGROUND: Neuroendocrine differentiation of prostatic carcinoma is known to be associated with a poor prognosis, tumor progression and androgen-independency, and there is currently no successful therapy for this type of tumor. The purpose of this study is to evaluate the prognostic implications of neuroendocrine differentiation in prostatic carcinoma in Korean men. METHODS: Six hundreds and ninety nine consecutive cases of radical prostatectomy specimens were systematically processed for topographic mapping. Neuroendocrine differentiation was detected by immunohistochemistry by using antibody to chromogranin. We analyzed the relationship between neuroendocrine differentiation and the clinicopathological prognostic factors, as well as biochemical failure. The neuroendocrine differentiation was evaluated according to the presence of chromogranin-positive cells, the pattern of neuroendocrine cells and the number of neuroendocrine cells, respectively. RESULTS: Neuroendocrine differentiation was detected in 150 out of 699 cases (21.5%). The presence of neuroendocrine differentiation as well as the pattern of neuroendocrine cells was correlated with biochemical failure and the other clinicopathological prognostic factors such as the Gleason score, the pathologic stage, the tumor volume, angiolymphatic invasion, perineural invasion, and the Ki-67 proliferative index (p<0.05). CONCLUSIONS: We suggest that neuroendocrine differentiation of prostatic carcinoma is a prognostic factor even in radical prostatectomy specimens for localized prostate cancer. Evaluation of the presence of neuroendocrine differentiation as well as the pattern of neuroendocrine cells is recommended in radical prostatectomy specimens.en
dc.description.sponsorship이 논문은 분당서울대학교병원 일반연구비에 의해 이루어진 것임(02-2007-012).en
dc.language.isokoen
dc.publisherThe Korean Society of Pathology = 대한병리학회en
dc.subjectProstateen
dc.subjectCarcinomaen
dc.subjectNeuroendocrine tumoren
dc.subjectChromograninen
dc.subjectPrognosisen
dc.title근치적 전립샘적출술을 시행한 699예의 전립샘암종에서 신경내분비 분화가 예후에 미치는 영향en
dc.title.alternativeThe Prognostic Significance of Neuroendocrine Differentiation for Treating Prostatic Carcinoma in 699 Cases of Radical Prostatectomyen
dc.typeArticleen
dc.contributor.AlternativeAuthorKang, Tae Hoon-
dc.contributor.AlternativeAuthorShin, Eun-
dc.contributor.AlternativeAuthorKim, Baek-Hee-
dc.contributor.AlternativeAuthorChoe, Gheeyoung-
dc.citation.journaltitleThe Korean Journal of Pathology (KJP) = 대한병리학회지-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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