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MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle

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dc.contributor.authorLee, You Jeong-
dc.contributor.authorJung, Kyeong Cheon-
dc.contributor.authorPark, Seong Hoe-
dc.date.accessioned2009-06-01T22:38:16Z-
dc.date.available2009-06-01T22:38:16Z-
dc.date.issued2008-11-25-
dc.identifier.citationImmunol Cell Biol 2008; 87: 65-71en
dc.identifier.issn0818-9641 (print)-
dc.identifier.issn1440-1711 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/4230-
dc.description.abstractUnlike conventional T cells, innate-like T cells such as natural killer (NK) T cells are selected by homotypic T-cell interactions. Recently, a few reports have shown that T-T CD4(+) T cells can be generated in a similar manner to that for NKT cells. These two types of cells share common functional properties such as rapid response to antigenic encounters and the potential for a panoply of cytokine secretion. However, T-T CD4(+) T cells differ from NKT cells in that they are restricted by highly polymorphic major histocompatibility complex (MHC) II molecules and have a diverse T-cell receptor repertoire. Additional example of T-T interactions was recently reported in which peripheral T cells re-circulate to the thymus and participate in the thymocyte selection process. In this review, we dissect the cellular mechanisms underlying the production of T-T CD4(+) and NKT cells, with particular emphasis on the differences between these two T-cell prototypes. Finally, we propose that T-T CD4(+) T cells serve two major functions: one as an acute-phase reactant against viral infection and the other is the generation of anti-ergotypic CD4(+) T cells for regulatory purposes. All of these features make it possible to create a diverse set of functional cells through MHC class II-restricted T-T interactions.en
dc.description.sponsorshipThis work was supported by a Korean Science and Engineering Foundation Grant (R01-2007-000-20165-0) from the Ministry of Knowledge Economy(MKE) of Korea.en
dc.language.isoen-
dc.publisherAustralasian Society for Immunologyen
dc.publisherWiley-Blackwell-
dc.subjectnon-conventional T cellen
dc.subjectre-circulationen
dc.subjectT–T CD4+ T cellen
dc.subjectT–T interactionen
dc.titleMHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circleen
dc.typeArticleen
dc.contributor.AlternativeAuthor이유정-
dc.contributor.AlternativeAuthor정경천-
dc.contributor.AlternativeAuthor박성호-
dc.identifier.doi10.1038/icb.2008.85-
dc.identifier.doi10.1038/icb.2008.85-
dc.citation.journaltitleImmunology and cell biology-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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