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MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle
DC Field | Value | Language |
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dc.contributor.author | Lee, You Jeong | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2009-06-01T22:38:16Z | - |
dc.date.available | 2009-06-01T22:38:16Z | - |
dc.date.issued | 2008-11-25 | - |
dc.identifier.citation | Immunol Cell Biol 2008; 87: 65-71 | en |
dc.identifier.issn | 0818-9641 (print) | - |
dc.identifier.issn | 1440-1711 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/4230 | - |
dc.description.abstract | Unlike conventional T cells, innate-like T cells such as natural killer (NK) T cells are selected by homotypic T-cell interactions. Recently, a few reports have shown that T-T CD4(+) T cells can be generated in a similar manner to that for NKT cells. These two types of cells share common functional properties such as rapid response to antigenic encounters and the potential for a panoply of cytokine secretion. However, T-T CD4(+) T cells differ from NKT cells in that they are restricted by highly polymorphic major histocompatibility complex (MHC) II molecules and have a diverse T-cell receptor repertoire. Additional example of T-T interactions was recently reported in which peripheral T cells re-circulate to the thymus and participate in the thymocyte selection process. In this review, we dissect the cellular mechanisms underlying the production of T-T CD4(+) and NKT cells, with particular emphasis on the differences between these two T-cell prototypes. Finally, we propose that T-T CD4(+) T cells serve two major functions: one as an acute-phase reactant against viral infection and the other is the generation of anti-ergotypic CD4(+) T cells for regulatory purposes. All of these features make it possible to create a diverse set of functional cells through MHC class II-restricted T-T interactions. | en |
dc.description.sponsorship | This work was supported by a Korean Science and Engineering Foundation Grant (R01-2007-000-20165-0) from the Ministry of Knowledge Economy(MKE) of Korea. | en |
dc.language.iso | en | - |
dc.publisher | Australasian Society for Immunology | en |
dc.publisher | Wiley-Blackwell | - |
dc.subject | non-conventional T cell | en |
dc.subject | re-circulation | en |
dc.subject | T–T CD4+ T cell | en |
dc.subject | T–T interaction | en |
dc.title | MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이유정 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 박성호 | - |
dc.identifier.doi | 10.1038/icb.2008.85 | - |
dc.identifier.doi | 10.1038/icb.2008.85 | - |
dc.citation.journaltitle | Immunology and cell biology | - |
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