S-Space College of Medicine/School of Medicine (의과대학/대학원) Microbiology (미생물학전공) Journal Papers (저널논문_미생물학전공)
Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells
- Shin, Jin-Young; Yoon, Il-Hee; Kim, Jung-Sik; Kim, Bongi; Park, Chung-Gyu
- Issue Date
- Cell Immunol. 2009;256(1-2):72-8. Epub 2009 Feb 26.
- Animals; Base Sequence; Cell Line; Cell Proliferation/drug effects; Chemotaxis, Leukocyte/*drug effects; DNA Primers/genetics; Humans; Immunologic Factors/*pharmacology; Immunotherapy; Interferon-gamma/biosynthesis; Interleukin-10/*biosynthesis; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Models, Immunological; Neoplasms/immunology/therapy; RNA, Messenger/genetics/metabolism; T-Lymphocytes/cytology/*drug effects/*immunology/physiology; Vascular Endothelial Growth Factor A/*pharmacology; Vascular Endothelial Growth Factor Receptor-1/genetics/metabolism; Vascular Endothelial Growth Factor Receptor-2/genetics/metabolism
- Vascular endothelial growth factor (VEGF) is a proangiogenic mediator that promotes tumor growth. The role of VEGF in T lymphocytes is unknown. We found that T lymphocytes activated by either anti-CD3 monoclonal antibody (mAb) plus anti-CD28 mAb or by antigens on antigen-presenting cells transcribed mRNA for VEGF receptor 1 (VEGFR1) and VEGFR2. However, only VEGFR1 was expressed on the T cell surface. The addition of VEGF to either resting or activated T cells did not affect their proliferation, but VEGF increased IL-10 production and slightly decreased IFN-gamma production. A chemotaxis assay revealed that activated T lymphocytes migrate in response to VEGF. Our data suggest that VEGF has a direct immunomodulatory effect on T cells. Engagement of a high concentration of VEGF with VEGFR1 on T cells may cause T cells to migrate to tumor sites, and this interaction may play a role in IL-10-mediated immune evasion by tumor cells.
- 1090-2163 (Electronic)
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