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Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells

DC Field Value Language
dc.contributor.authorGil, Jung-Eun-
dc.contributor.authorWoo, Dong-Hun-
dc.contributor.authorShim, Joong-Hyun-
dc.contributor.authorKim, Sung-Eun-
dc.contributor.authorYou, Hyun-Ju-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorPaek, Sun Ha-
dc.contributor.authorKim, Suel-Kee-
dc.contributor.authorKim, Jong-Hoon-
dc.date.accessioned2009-06-12T08:07:25Z-
dc.date.available2009-06-12T08:07:25Z-
dc.date.issued2009-01-24-
dc.identifier.citationFEBS Lett. 583, 561-567en
dc.identifier.issn0014-5793 (print)-
dc.identifier.issn1873-3468 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/4613-
dc.description.abstractWe demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that proliferate and differentiate into oligodendrocytes in response to mitogenic and survival factors. These results support the beneficial effect of VN on oligodendrocytic differentiation of hESCs.en
dc.description.sponsorshipThis research was supported by the Seoul Research and Business Development Program (10574) and by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea Government(MOST) (R01-2006-000-11364-0).en
dc.language.isoen-
dc.publisherthe Federation of European Biochemical Societiesen
dc.publisherElsevier-
dc.subjectHuman embryonic stem cellsen
dc.subjectOligodendrocytesen
dc.subjectVitronectinen
dc.subjectDifferentiationen
dc.titleVitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor길정은-
dc.contributor.AlternativeAuthor우동훈-
dc.contributor.AlternativeAuthor심중현-
dc.contributor.AlternativeAuthor김성은-
dc.contributor.AlternativeAuthor유현주-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor백선하-
dc.contributor.AlternativeAuthor김슬기-
dc.contributor.AlternativeAuthor김종훈-
dc.identifier.doi10.1016/j.febslet.2008.12.061-
dc.identifier.doi10.1016/j.febslet.2008.12.061-
dc.citation.journaltitleFEBS letters-
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