Publications
Detailed Information
Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gil, Jung-Eun | - |
dc.contributor.author | Woo, Dong-Hun | - |
dc.contributor.author | Shim, Joong-Hyun | - |
dc.contributor.author | Kim, Sung-Eun | - |
dc.contributor.author | You, Hyun-Ju | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Suel-Kee | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.date.accessioned | 2009-06-12T08:07:25Z | - |
dc.date.available | 2009-06-12T08:07:25Z | - |
dc.date.issued | 2009-01-24 | - |
dc.identifier.citation | FEBS Lett. 583, 561-567 | en |
dc.identifier.issn | 0014-5793 (print) | - |
dc.identifier.issn | 1873-3468 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/4613 | - |
dc.description.abstract | We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that proliferate and differentiate into oligodendrocytes in response to mitogenic and survival factors. These results support the beneficial effect of VN on oligodendrocytic differentiation of hESCs. | en |
dc.description.sponsorship | This research was supported by the Seoul Research and Business Development Program (10574) and by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea Government(MOST) (R01-2006-000-11364-0). | en |
dc.language.iso | en | - |
dc.publisher | the Federation of European Biochemical Societies | en |
dc.publisher | Elsevier | - |
dc.subject | Human embryonic stem cells | en |
dc.subject | Oligodendrocytes | en |
dc.subject | Vitronectin | en |
dc.subject | Differentiation | en |
dc.title | Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 길정은 | - |
dc.contributor.AlternativeAuthor | 우동훈 | - |
dc.contributor.AlternativeAuthor | 심중현 | - |
dc.contributor.AlternativeAuthor | 김성은 | - |
dc.contributor.AlternativeAuthor | 유현주 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김슬기 | - |
dc.contributor.AlternativeAuthor | 김종훈 | - |
dc.identifier.doi | 10.1016/j.febslet.2008.12.061 | - |
dc.identifier.doi | 10.1016/j.febslet.2008.12.061 | - |
dc.citation.journaltitle | FEBS letters | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.