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Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

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dc.contributor.authorCho, Y M-
dc.contributor.authorKim, T H-
dc.contributor.authorLim, S-
dc.contributor.authorChoi, S H-
dc.contributor.authorShin, H D-
dc.contributor.authorLee, H K-
dc.contributor.authorPark, K S-
dc.contributor.authorJang, H C-
dc.date.accessioned2010-01-28T08:03:29Z-
dc.date.available2010-01-28T08:03:29Z-
dc.date.issued2008-11-13-
dc.identifier.citationDiabetologia. 2009 Feb;52(2):253-61. Epub 2008 Nov 11.en
dc.identifier.issn1432-0428 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19002430-
dc.identifier.urihttp://www.springerlink.com/content/h6234qr522328153/fulltext.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/46295-
dc.description.abstractAIMS/HYPOTHESIS: New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS: The study included 869 Korean women with GDM and 345 female and 287 male Korean non-diabetic controls. We genotyped the single nucleotide polymorphisms (SNPs) rs7756992 and rs7754840 in CDKAL1; rs564398, rs1333040, rs10757278 and rs10811661 in the CDKN2A-CDKN2B region; rs8050136 in FTO; rs1111875, rs5015480 and rs7923837 in HHEX; rs4402960 in IGF2BP2; and rs13266634 in SLC30A8. In addition, rs7903146 and rs12255372 in TCF7L2; rs5215 and rs5219 in KCNJ11; and rs3856806 and rs1801282 in PPARG were genotyped. The genotype frequencies in the GDM patients were compared with those in the non-diabetic controls. RESULTS: Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2. The risk alleles of the SNPs rs7756992 and rs7754840 in CDKAL1; rs10811661 in the CDKN2A-CDKN2B region; and rs1111875, rs5015480 and rs7923837 in HHEX were associated with significant decreases in the insulin AUC during a 100 g OGTT performed at the time of diagnosis of GDM. CONCLUSIONS/INTERPRETATION: Some of the type 2 diabetes-associated genetic variants that were discovered in the recent GWA studies are also associated with GDM in Koreans.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectChromosome Mappingen
dc.subjectDiabetes Mellitus, Type 2/*geneticsen
dc.subjectDiabetes, Gestational/*geneticsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectPregnancyen
dc.subjectProteins/geneticsen
dc.subjectRNA-Binding Proteins/geneticsen
dc.subjectGenetic Variation-
dc.subjectGenome, Human-
dc.subjectGenome-Wide Association Study-
dc.subjectPolymorphism, Single Nucleotide-
dc.titleType 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean populationen
dc.typeArticleen
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor김태혁-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor이홍규-
dc.identifier.doi10.1007/s00125-008-1196-4-
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