Publications
Detailed Information
Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
Cited 126 time in
Web of Science
Cited 148 time in Scopus
- Authors
- Issue Date
- 2009-01-08
- Publisher
- Nature Publishing Group
- Citation
- Br J Cancer. 2009 Jan 27;100(2):298-304. Epub 2009 Jan 6.
- Keywords
- Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Female ; Fluorouracil/administration & dosage ; Humans ; Leucovorin/administration & dosage ; Liver Neoplasms/chemistry/*drug therapy/secondary ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis/drug therapy ; Neoplasm Staging ; Organoplatinum Compounds/administration & dosage ; Peritoneal Neoplasms/chemistry/*drug therapy/secondary ; Prognosis ; Prospective Studies ; Stomach Neoplasms/chemistry/*drug therapy/pathology ; Survival Rate ; Treatment Outcome ; Tumor Markers, Biological/*analysis
- Abstract
- This prospective study was conducted with the Korean Cancer Study Group to evaluate the efficacy and safety of cetuximab combined with modified FOLFOX6 (mFOLFOX6) as first-line treatment in recurrent or metastatic gastric cancer and to identify potential predictive biomarkers. Patients received cetuximab 400 mg m(-2) at week 1 and 250 mg m(-2) weekly thereafter until disease progression. Oxaliplatin (100 mg m(-2)) and leucovorin (100 mg m(-2)) were administered as a 2-h infusion followed by a 46-h continuous infusion of 5-fluorouracil (2400 mg m(-2)) every 2 weeks for a maximum of 12 cycles. Biomarkers potentially associated with efficacy were analysed. Among 38 evaluable patients, confirmed response rate (RR) was 50.0% (95% CI 34.1-65.9). Median time-to-progression (TTP) was 5.5 months (95% CI 4.5-6.5) and overall survival (OS) 9.9 months. Eleven patients having tumour EGFR expression by immunohistochemistry with low serum EGF and TGF-alpha levels showed a 100% RR compared to 37.0% in the remaining 27 patients (P<0.001). Moreover, ligand level increased when disease progressed in seven out of eight patients with EGFR expression and low baseline ligand level. No patient exhibited EGFR amplification or K-ras mutations. Gastric cancer patients with EGFR expression and low ligand levels had better outcomes with cetuximab/mFOLFOX6 treatment.
- ISSN
- 1532-1827 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19127259
http://www.nature.com/bjc/journal/v100/n2/pdf/6604861a.pdf
https://hdl.handle.net/10371/46307
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.