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Korean ginseng-induced occupational asthma and determination of IgE binding components

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dc.contributor.authorKim, Kyung-Mook-
dc.contributor.authorKwon, Hyouk-Soo-
dc.contributor.authorJeon, Sung-Gyu-
dc.contributor.authorPark, Chang-Han-
dc.contributor.authorSohn, Seong-Wook-
dc.contributor.authorKim, Duck-in-
dc.contributor.authorKim, Sun-Sin-
dc.contributor.authorChang, Yoon-Seok-
dc.contributor.authorKim, Yoon-Keun-
dc.contributor.authorCho, Sang-Heon-
dc.contributor.authorMin, Kyung-Up-
dc.contributor.authorKim, You-Young-
dc.date.accessioned2010-01-28T08:27:10Z-
dc.date.available2010-01-28T08:27:10Z-
dc.date.issued2008-03-26-
dc.identifier.citationJ Korean Med Sci. 2008 Apr;23(2):232-5.en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18437005-
dc.identifier.urihttp://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-23-232.pdf-
dc.identifier.urihttp://hdl.handle.net/10371/46309-
dc.description.abstractA number of case reports on occupational asthma caused by herbal medicines have been issued, for example, on Sanyak, Chunkung, Banha, and Brazilian ginseng. Recently, cases of occupational asthma induced by Sanyak and Korean ginseng have been reported, but the pathogenic mechanisms involved are unknown. This study was carried out to evaluate the immunologic mechanism underlying Korean ginseng-induced occupational asthma. A patient engaged in Korean ginseng wholesale was referred for recurrent dyspnea, wheezing, and nasal symptoms, which were aggravated at work. Allergen bronchial provocation testing to Korean ginseng extract showed a typical immediate response, and skin prick testing to Korean ginseng extract also showed a strong positive response. Moreover, serum-specific IgE levels to Korean ginseng extract were significantly higher than in controls. Enzyme-linked immunosorbent assay (ELISA) inhibition tests showed a dose-dependent inhibition by Korean ginseng, but not by Dermatophagoides farinae, wheat flour, or Chinese balloon flower. Sodium dodecylsulfate-poly-acrylamide gel electrophoresis (SDS-PAGE) and immunoblotting revealed four specific Immunoglobulin E (IgE) binding components at 26, 30, 47, and 60 kDa, which were not bound by control sera. These results strongly suggest that occupation asthma induced by Korean ginseng is induced via an IgE-mediated mechanism.en
dc.language.isoenen
dc.publisherKorean Academy of Medical Scienceen
dc.subjectAnimalsen
dc.subjectAsthma/diagnosis/*etiology/*immunologyen
dc.subjectBronchi/metabolismen
dc.subjectElectrophoresis, Polyacrylamide Gelen
dc.subjectEnzyme-Linked Immunosorbent Assay/methodsen
dc.subjectFlouren
dc.subjectFlowersen
dc.subjectHumansen
dc.subjectHypersensitivity/*diagnosisen
dc.subjectImmunoglobulin E/analysis/*chemistryen
dc.subjectKoreaen
dc.subjectOccupational Diseases/diagnosis/*etiology/*immunologyen
dc.subjectPanax/*adverse effectsen
dc.subjectPyroglyphidae/metabolismen
dc.subject*Skin Testsen
dc.titleKorean ginseng-induced occupational asthma and determination of IgE binding componentsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김경묵-
dc.contributor.AlternativeAuthor권혁수-
dc.contributor.AlternativeAuthor전성규-
dc.contributor.AlternativeAuthor박창한-
dc.contributor.AlternativeAuthor손성욱-
dc.contributor.AlternativeAuthor김덕인-
dc.contributor.AlternativeAuthor김순신-
dc.contributor.AlternativeAuthor장윤석-
dc.contributor.AlternativeAuthor김윤근-
dc.contributor.AlternativeAuthor조상현-
dc.contributor.AlternativeAuthor민경업-
dc.contributor.AlternativeAuthor김유영-
dc.identifier.doi10.3346/jkms.2008.23.2.232-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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