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Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Sung-E | - |
dc.contributor.author | Kim, Hyo-Eun | - |
dc.contributor.author | Shin, Ha-Chul | - |
dc.contributor.author | Jang, Hyun-Ju | - |
dc.contributor.author | Lee, Kwan-Woo | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Kang, Sang Sun | - |
dc.contributor.author | Chun, Jaesun | - |
dc.contributor.author | Kang, Yup | - |
dc.date.accessioned | 2010-01-29T02:06:01Z | - |
dc.date.available | 2010-01-29T02:06:01Z | - |
dc.date.issued | 2007-05-18 | - |
dc.identifier.citation | Mol Cell Endocrinol. 2007 Jun 30;272(1-2):50-62. Epub 2007 Apr 22. | en |
dc.identifier.issn | 0303-7207 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3G-4NJG43R-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3f24636290dffb9e5750e5126026229a | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17507155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/46604 | - |
dc.description.abstract | The extracellular Ca(2+) chelator EGTA and L-type Ca(2+) channel blockers, such as, nifedipine and nimodipine were found to have a protective effect on palmitate-induced MIN6N8a beta cell apoptosis, whereas the Ca(2+) channel opener, Bay K8644, enhanced the apoptotic process. Moreover, the phospho-form of Bad, in conjunction with phospho-Akt, was reduced in response to palmitate and the palmitate-induced dephosphorylations of Akt and Bad were dependent on Ca(2+) influx. The transient expression of catalytically active Akt prevented MIN6N8a cells from palmitate-induced apoptosis. Deltamethrin, an inhibitor of Ca(2+)-activated phosphatase, delayed Akt and Bad dephosphorylations, and then protected MIN6N8a cells from palmitate-induced apoptosis. On the other hand, palmitate was found to induce CHOP, an apoptotic transcription factor in response to ER stress, and this induction was enhanced by Ca(2+) influx. Our studies suggested that Ca(2+) influx and subsequent Ca(2+)-mediated apoptotic signals are involved in palmitate-induced beta cell death. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Apoptosis/*drug effects | en |
dc.subject | Calcineurin/physiology | en |
dc.subject | Calcium/antagonists & inhibitors/*physiology | en |
dc.subject | Cell Death/drug effects | en |
dc.subject | Cell Line | en |
dc.subject | Chelating Agents/pharmacology | en |
dc.subject | Endoplasmic Reticulum/drug effects | en |
dc.subject | Insulin-Secreting Cells/*drug effects/physiology | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Oncogene Protein v-akt/metabolism | en |
dc.subject | Palmitic Acid/*pharmacology | en |
dc.subject | Protective Agents/pharmacology | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | bcl-Associated Death Protein/metabolism | en |
dc.title | Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최성이 | - |
dc.contributor.AlternativeAuthor | 김효은 | - |
dc.contributor.AlternativeAuthor | 신하철 | - |
dc.contributor.AlternativeAuthor | 장현주 | - |
dc.contributor.AlternativeAuthor | 이관우 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.contributor.AlternativeAuthor | 강상선 | - |
dc.contributor.AlternativeAuthor | 천재선 | - |
dc.contributor.AlternativeAuthor | 강엽 | - |
dc.identifier.doi | 10.1016/j.mce.2007.04.004 | - |
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