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Angiogenesis in skin aging and photoaging

Cited 74 time in Web of Science Cited 81 time in Scopus
Authors
Chung, Jin Ho; Eun, Hee Chul
Issue Date
2007-08-31
Publisher
Wiley-Blackwell
Citation
J Dermatol. 2007 Sep;34(9):593-600.
Keywords
Dermatologic Agents/*pharmacologyHot Temperature/adverse effectsHumansInfrared Rays/adverse effectsMetalloproteases/metabolismNeovascularization, Pathologic/*physiopathologySkin/blood supply/*pathology/radiation effectsSkin Aging/drug effects/*physiology/radiation effectsTretinoin/*pharmacologyUltraviolet Rays/*adverse effectsVascular Endothelial Growth Factor A/metabolism
Abstract
Angiogenesis, the process of generating new blood vessels, is affected by various physiological and pathological conditions of skin. The skin aging process can be divided into intrinsic aging and photoaging. With aging, cutaneous blood vessels undergo pronounced alterations. A reduction of the cutaneous microvasculature has been observed in the skin of elderly individuals. Human skin is exposed daily to solar ultraviolet (UV) radiation, infrared rays and heat, and these stimuli are known to induce skin angiogenesis. Interestingly, although acute UV irradiation stimulates skin angiogenesis, cutaneous blood vessels are decreased in chronically photodamaged skin. The reason for the differential effects of acute and chronic UV exposure on skin angiogenesis remains to be elucidated. This review discusses the vascularization changes in intrinsically aged and photoaged human skin, the effects of UV irradiation, infrared rays and heat on skin angiogenesis, and the effects of topical retinoic acid treatment on UV-induced angiogenesis and cutaneous vascularity in aged and photoaged human skin. An understanding of the molecular mechanisms of aging- and photoaging-dependent changes of skin angiogenesis may provide us with new insights to prevent and treat the skin aging process.
ISSN
0385-2407 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17727362

https://hdl.handle.net/10371/46607
DOI
https://doi.org/10.1111/j.1346-8138.2007.00341.x
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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