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Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, You Jin | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Shin, Chan Soo | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Kim, Seong Yeon | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.date.accessioned | 2010-01-29T04:20:00Z | - |
dc.date.available | 2010-01-29T04:20:00Z | - |
dc.date.issued | 2007-10-06 | - |
dc.identifier.citation | J Korean Med Sci. 2007 Oct;22(5):883-90. | en |
dc.identifier.issn | 1011-8934 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17982240 | - |
dc.identifier.uri | https://hdl.handle.net/10371/46658 | - |
dc.description.abstract | To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the changes in gene expression. The expressions of genes for bone morphogenetic protein 6, the glucagon receptor, and cyclin D1 were increased by both TSH and IGF-1; for cytochrome P450, 2c37, the expression was decreased by both. Genes for cholecystokinin, glucuronidase, beta, demethyl-Q 7, and cytochrome c oxidase, subunit VIIIa, were up-regulated; the genes for ribosomal protein L37 and ribosomal protein L4 were down-regulated by TSH and insulin. However, there was no gene observed to be regulated by all three: TSH, IGF-1, and insulin molecules studied. These findings suggest that TSH, IGF-1, and insulin stimulate different signal pathways, which can interact with one another to regulate the proliferation of thyrocytes, and thereby provide additional influence on the process of cellular proliferation. | en |
dc.language.iso | en | - |
dc.publisher | Korean Academy of Medical Science | en |
dc.subject | Animals | en |
dc.subject | Bone Morphogenetic Protein 6 | en |
dc.subject | Bone Morphogenetic Proteins/biosynthesis | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cyclin D1/biosynthesis | en |
dc.subject | Insulin/*biosynthesis/metabolism | en |
dc.subject | Insulin-Like Growth Factor I/*biosynthesis | en |
dc.subject | Models, Genetic | en |
dc.subject | Rats | en |
dc.subject | Receptors, Glucagon/biosynthesis | en |
dc.subject | Thyroid Gland/*metabolism | en |
dc.subject | Thyrotropin/*biosynthesis/metabolism | en |
dc.subject | Time Factors | en |
dc.subject | Gene Expression Profiling | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Oligonucleotide Array Sequence Analysis | - |
dc.title | Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이유진 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 신찬수 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 김성연 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.contributor.AlternativeAuthor | 조보연 | - |
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