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Antioxidant effect of Inonotus obliquus

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dc.contributor.authorCui, Yong-
dc.contributor.authorKim, Dong-Seok-
dc.contributor.authorPark, Kyoung-Chan-
dc.date.accessioned2010-01-29T06:44:19Z-
dc.date.available2010-01-29T06:44:19Z-
dc.date.issued2004-12-14-
dc.identifier.citationJ Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.en
dc.identifier.issn0378-8741 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15588653-
dc.identifier.urihttp://dx.dor.org/10.1016/j.jep.2004.08.037-
dc.identifier.urihttp://hdl.handle.net/10371/46960-
dc.description.abstractThe mushroom Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae), has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. The purpose of this study was to elucidate the antioxidant capacities of Inonotus obliquus. Four extracts from the fungus were evaluated for antioxidant activity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide, and peroxyl radicals. The polyphenolic extract had a strong antioxidant activity, and the extract containing triterpenoids and steroids presented a relatively strong antioxidant effect. The polysaccharide extract, however, was inactive. The protective effects of these four extracts were assessed against hydrogen peroxide-induced oxidative stress using a human keratinocyte cell line, HaCaT. Our results show that the polyphenolic extract protected these cells against hydrogen peroxide-induced oxidative stress, while the polysaccharide, triterpenoid and steroid extracts were ineffective. Additionally, the remnant polyphenolic and low molecular weight polysaccharide extracts showed a weakly protective effect at a concentration of 50 microg/ml. Our results indicate that Inonotus obliquus has the capacity to scavenge free radicals at concentrations higher than 5 microg/ml and that the polyphenolic extract can protect cells against oxidative stress.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAntioxidants/chemistry/isolation & purification/*pharmacologyen
dc.subjectAscorbic Acid/pharmacologyen
dc.subject*Basidiomycotaen
dc.subjectCell Lineen
dc.subjectFlavonoids/pharmacologyen
dc.subjectFree Radical Scavengers/chemistry/isolation & purification/pharmacologyen
dc.subjectHumansen
dc.subjectKeratinocytes/drug effectsen
dc.subjectOxidative Stress/drug effectsen
dc.subjectPhenols/pharmacologyen
dc.subjectPolysaccharides/pharmacologyen
dc.titleAntioxidant effect of Inonotus obliquusen
dc.typeArticleen
dc.contributor.AlternativeAuthor최용-
dc.contributor.AlternativeAuthor김동석-
dc.contributor.AlternativeAuthor박경찬-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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