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Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis

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dc.contributor.authorKim, Dong-Seok-
dc.contributor.authorKim, So-Young-
dc.contributor.authorPark, Seo-Hyoung-
dc.contributor.authorChoi, Yeong-Gon-
dc.contributor.authorKwon, Sun-Bang-
dc.contributor.authorKim, Myo-Kyoung-
dc.contributor.authorNa, Jung-Im-
dc.contributor.authorYoun, Sang-Woong-
dc.contributor.authorPark, Kyoung-Chan-
dc.date.accessioned2010-01-29T06:56:58Z-
dc.date.available2010-01-29T06:56:58Z-
dc.date.issued2005-12-06-
dc.identifier.citationBiol Pharm Bull. 2005 Dec;28(12):2216-9.en
dc.identifier.issn0918-6158 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16327152-
dc.identifier.urihttp://hdl.handle.net/10371/46977-
dc.description.abstractIn this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase.en
dc.language.isoenen
dc.publisherPharmaceutical Society of Japanen
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectCell Lineen
dc.subjectCell Survival/drug effectsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDown-Regulation/drug effectsen
dc.subjectDrug Combinationsen
dc.subjectDrug Synergismen
dc.subjectHumansen
dc.subjectHypopigmentation/chemically induced/metabolismen
dc.subjectMelanins/*antagonists & inhibitors/*biosynthesis/chemistryen
dc.subjectMiceen
dc.subjectMicrophthalmia-Associated Transcription Factor/antagonists &en
dc.subjectinhibitors/chemistry/drug effectsen
dc.subjectMonophenol Monooxygenase/*antagonists & inhibitors/drug effects/metabolismen
dc.subjectMonoterpenes/chemistry/pharmacologyen
dc.subjectResorcinols/chemistry/*pharmacologyen
dc.subjectSignal Transduction/drug effectsen
dc.subjectSkin Pigmentationen
dc.subjectTropolone/analogs & derivatives/chemistry/pharmacologyen
dc.titleInhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesisen
dc.typeArticleen
dc.contributor.AlternativeAuthor김동석-
dc.contributor.AlternativeAuthor김소영-
dc.contributor.AlternativeAuthor박서형-
dc.contributor.AlternativeAuthor최영곤-
dc.contributor.AlternativeAuthor권선방-
dc.contributor.AlternativeAuthor김묘경-
dc.contributor.AlternativeAuthor나정임-
dc.contributor.AlternativeAuthor윤상웅-
dc.contributor.AlternativeAuthor박경찬-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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