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Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Kim, So-Young | - |
dc.contributor.author | Park, Seo-Hyoung | - |
dc.contributor.author | Choi, Yeong-Gon | - |
dc.contributor.author | Kwon, Sun-Bang | - |
dc.contributor.author | Kim, Myo-Kyoung | - |
dc.contributor.author | Na, Jung-Im | - |
dc.contributor.author | Youn, Sang-Woong | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.date.accessioned | 2010-01-29T06:56:58Z | - |
dc.date.available | 2010-01-29T06:56:58Z | - |
dc.date.issued | 2005-12-06 | - |
dc.identifier.citation | Biol Pharm Bull. 2005 Dec;28(12):2216-9. | en |
dc.identifier.issn | 0918-6158 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16327152 | - |
dc.identifier.uri | https://hdl.handle.net/10371/46977 | - |
dc.description.abstract | In this study, we investigated the effects of 4-n-butylresorcinol on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Our results show that 4-n-butylresorcinol significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. Several reports have indicated that the activation of extracellular signal-regulated kinase (ERK) or of Akt reduces melanin synthesis via microphthalmia-associated transcription factor (MITF) down-regulation. Accordingly, we examined the effects of 4-n-butylresorcinol on the ERK and Akt signaling pathways. 4-n-Butylresorcinol did not induce ERK, Akt activation, or MITF degradation, and had no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. In contrast, 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression. These results show that the hypopigmentary effect of 4-n-butylresorcinol results from its direct inhibition of tyrosinase. | en |
dc.language.iso | en | en |
dc.publisher | Pharmaceutical Society of Japan | en |
dc.subject | Animals | en |
dc.subject | Blotting, Western | en |
dc.subject | Cell Line | en |
dc.subject | Cell Survival/drug effects | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Down-Regulation/drug effects | en |
dc.subject | Drug Combinations | en |
dc.subject | Drug Synergism | en |
dc.subject | Humans | en |
dc.subject | Hypopigmentation/chemically induced/metabolism | en |
dc.subject | Melanins/*antagonists & inhibitors/*biosynthesis/chemistry | en |
dc.subject | Mice | en |
dc.subject | Microphthalmia-Associated Transcription Factor/antagonists & | en |
dc.subject | inhibitors/chemistry/drug effects | en |
dc.subject | Monophenol Monooxygenase/*antagonists & inhibitors/drug effects/metabolism | en |
dc.subject | Monoterpenes/chemistry/pharmacology | en |
dc.subject | Resorcinols/chemistry/*pharmacology | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | Skin Pigmentation | en |
dc.subject | Tropolone/analogs & derivatives/chemistry/pharmacology | en |
dc.title | Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김동석 | - |
dc.contributor.AlternativeAuthor | 김소영 | - |
dc.contributor.AlternativeAuthor | 박서형 | - |
dc.contributor.AlternativeAuthor | 최영곤 | - |
dc.contributor.AlternativeAuthor | 권선방 | - |
dc.contributor.AlternativeAuthor | 김묘경 | - |
dc.contributor.AlternativeAuthor | 나정임 | - |
dc.contributor.AlternativeAuthor | 윤상웅 | - |
dc.contributor.AlternativeAuthor | 박경찬 | - |
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