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Efffects of pain inducing agents on voltage dependent calcium currents in the trigeminal ganglion

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dc.contributor.authorPark, Kyungpyo-
dc.contributor.authorKim, Seong-Ah-
dc.contributor.authorKim, Youn-Bae-
dc.contributor.authorKim, Joong-Soo-
dc.contributor.authorLee, Jong-Heun-
dc.date.accessioned2010-02-01T06:00:25Z-
dc.date.available2010-02-01T06:00:25Z-
dc.date.issued2001-04-
dc.identifier.citationInternational Journal of Oral Biology 26:1-6, 2001.en
dc.identifier.issn1225-6390-
dc.identifier.urihttp://hdl.handle.net/10371/47209-
dc.description.abstractTrigeminal ganglion (TG) neurons are primary sensory neurons involved in the transmission of orofacial sensation, including pain. It is known that intracellular free calcium concentration plays a critical role in neurotransmitter release. In the present study, we examined the effects of pain-inducing agents, bradykinin and histamine, on voltage dependent Ca^2+ current (I_Ca) and compared these with the effects of the analgesic agent, eugenol. I_Ca was measured using a whole-cell patch clamp method. Bradykinin (10μM) inhibited I_Ca in TG neurons. Maximum inward I_Ca was reduced by 26% by bradykinin compared with the controls (n=13, p<0.05). Decreased I_Ca induced by bradykinin did not recover to the prestimulus level after washing out bradykinin. In contrast, histamine (100μM) increased I_Ca by 25% compared with controls (n=7,p<0.05) in an irreversible manner. Eugenol (250μM), commonly used to produce analgesia in dental clinics, decreased I_Ca to 22.6% (n=9,p<0.05) and this effect on the I_Ca was reversible. although the effect of eugenol on the I_Ca was consistent, the effects of the two pain-inducing agents, bradykinin and histamine, were different. Our results suggest that the modulation of I_Ca in TG neurons is not a decisive factor underlying the pain mechanism evoked by pain-inducing agents.en
dc.language.isoenen
dc.publisherThe Korean Academy of Oral Biologyen
dc.subjecttrigeminal ganglion(TG)en
dc.subjectvoltage dependent Ca^2+ current(I_Ca)en
dc.subjectbradykininen
dc.subjecthistamineen
dc.subjecteugenolen
dc.titleEfffects of pain inducing agents on voltage dependent calcium currents in the trigeminal ganglionen
dc.typeArticleen
dc.contributor.AlternativeAuthor박경표-
dc.contributor.AlternativeAuthor김성아-
dc.contributor.AlternativeAuthor김연배-
dc.contributor.AlternativeAuthor김종수-
dc.contributor.AlternativeAuthor이종현-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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