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Effects of PVA sponge containing chitooligosaccharide in the early stage of wound healing

Cited 39 time in Web of Science Cited 42 time in Scopus
Authors
Min, Byung-Moo; You, Young; Park, Won-Ho; Ko, Bub-Min
Issue Date
2004-03
Publisher
Springer Verlag
Citation
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 15 (2004) 297-301.
Abstract
Poly(vinyl alcohol) (PVA) sponges with different chitooligosaccharide (COS) content were prepared for wound-dressing application. The morphological structure of PVA sponges was observed by scanning electron microscopy. As the concentration of COS-loaded PVA sponge increased, the average pore size of sponge decreased and the release rate of COS from the sponge also slightly decreased. The accelerating effect of the COS-loaded PVA sponges on open wound healing in rats was investigated by macroscopic examination and measurement of wound area. The COS-loaded sponges were found to be very effective as a wound-healing accelerator in the early stage of wound healing. The wound treated with the COS-loaded PVA sponge was almost reepithelialized, granulation tissues in the wound were considerably replaced by fibrosis at 8 days after initial wounding. The COS-loaded PVA sponge was considered to be a suitable wound-healing formulation due to its easy preparation and high effectiveness
ISSN
0957-4530
Language
English
URI
https://hdl.handle.net/10371/47240
DOI
https://doi.org/10.1023/B:JMSM.0000015491.91918.64
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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