골대체물로서의 치아인회석: 동물실험과 임상적 적용 연구

Abstract

The purpose of this study is to evaluate the usefulness of calcined teeth powder as biological apatite. The animal experiment was performed in 36 rabbits aging 6 weeks and weighing 1.6kg. in experimental group, tooth apatite powder was implanted to 10mm bony defects in diameter made on the cranial bone of the rabbits. As control groups, synthetic porous hydroxyapatite and resorbable type calcium carbonate were implanted to the defects of same size. Each group was sacrified in 1, 2, 4, 6, 8, 12 weeks after the surgery. Specimen were prepared for decalcified samples and observed by a light microscope. And we also performed quantitative analysis of new bone formation through image analysis using computer. In clinical applications, we used tooth apatite alone or mixed with decalcified freeze-dried bone for reconstruction of bony defects in 15 patients undergone enucleation of cyst or ameloblastoma. @ES The obtained results were as follows: @EN 1. The powder of the calcined teeth was called as "tooth apatite" and it seemed to have biocompatibility in rabbits and human. 2. In group of tooth apatite, after 4weeks of operation, new bone directly bonded to the particles was observed. And in 12 weeks of it. New bone occupied most of the bony defects. In 6 weeks, resorption of the tooth apatite particles was observed. Thus the tooth apatite was regarded as one of resorbable apatite. 3. The group of tooth apatite showed new bone fornation similar to the group of porous hydroxyapatite, but they were inferior to the group of resorbable calcium carbonate. 4. In clinical application, tooth apatite had biocompatibility and new bone for 1 cases. So we think it is a useful bone bone substitute with osteoconductivity.