Browse

5-Lipoxygenase 대사산물들이 파골세포 생성에 미치는 영향
Effects of 5-Lipoxygenase Matabolites on the Osteoclast Fromation

DC Field Value Language
dc.contributor.authorKim, Hyo-Jin-
dc.contributor.authorBaek, Jeong-Hwa-
dc.contributor.authorKim, Gwan-Shik-
dc.date.accessioned2010-02-01T06:04:08Z-
dc.date.available2010-02-01T06:04:08Z-
dc.date.issued1998-10-
dc.identifier.citation대한치과의사학회지 1998;353:706~12en
dc.identifier.issn1226-9638-
dc.identifier.urihttps://hdl.handle.net/10371/47277-
dc.description.abstractSince 5-iipoxygenase metabolites production is known, to be enhanced in inflammed and malignant tissues which are associated with local bone destruction, ´ it is likely that 5iipoxygenase metabolites play some ro´,es in bone destruction. Therefore .ve performed this study to ´find out the effect of 5lipoxygenase metabolites on the osteoclast formation. Coculture of neonatal mouse calvarial osteoblastic cells and mouse bone ma-row cells was established and cultured for 7 days. After the culture, staining for tartrateresistant ac´ol phosphatase, a marker enzyme of osteoclast, was executed and the number of tartrateresistant acid ´phosphatase positive multinucleated cells was counted. 1,25-dhydroxyvitamn D; and tumor necrosis factor a significantly stimulated the osteoclast formation. When 5lipoxygenase pathway was blocked by caffeic acid, 1,25dihydroxyvitamin D, or tumor ´necrosis
factor- a -induced osteoclast formation was significantly
inhibited. Furthermore, when both cyclooxygenase and 54poxygenase pathway were blocked by combined treatment of indomethaoin and caffeic acid, 1,25dhydroxyvitamin D, o-tumor necrosis factor a -induced osteoclast formation was almost completely inhibited. Though phospholipase A, or meilitin failed to induce osteoclast formation- sy themselves, they
significantly enhanced 1,25dihydroxyvitamin D:induced osteoclast formation. And caffeic acid partly , inh!Lted the osteoclast formation induced by comD´ned t7eatment of phospholipase A, and 125dihydroxyvitarrin D, or meliftur and 1,25dihydroxyvitamin D;. Taken toge her, 5lipoxygenase metabolites seem to have certain role(3) in the osteoc:ast formation induced by 1,25dihydroxyvitamin D; or tumor necrosis factora and in the local bone destruction associated with inflammation by enhancing osteoclast fDrmation.
en
dc.language.isokoen
dc.publisher대한치과의사학회en
dc.subject1,25-dihydroxyvitamin D₃en
dc.subject5-Lipoxygenase metaboliteen
dc.title5-Lipoxygenase 대사산물들이 파골세포 생성에 미치는 영향en
dc.title.alternativeEffects of 5-Lipoxygenase Matabolites on the Osteoclast Fromationen
dc.typeArticleen
dc.contributor.AlternativeAuthor김효진-
dc.contributor.AlternativeAuthor백전화-
dc.contributor.AlternativeAuthor김관식-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse