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5-Lipoxygenase 대사산물들이 파골세포 생성에 미치는 영향 : Effects of 5-Lipoxygenase Matabolites on the Osteoclast Fromation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyo-Jin | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.contributor.author | Kim, Gwan-Shik | - |
dc.date.accessioned | 2010-02-01T06:04:08Z | - |
dc.date.available | 2010-02-01T06:04:08Z | - |
dc.date.issued | 1998-10 | - |
dc.identifier.citation | 대한치과의사학회지 1998;353:706~12 | en |
dc.identifier.issn | 1226-9638 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47277 | - |
dc.description.abstract | Since 5-iipoxygenase metabolites production is known, to be enhanced in inflammed and malignant tissues which are associated with local bone destruction, ´ it is likely that 5iipoxygenase metabolites play some ro´,es in bone destruction. Therefore .ve performed this study to ´find out the effect of 5lipoxygenase metabolites on the osteoclast formation. Coculture of neonatal mouse calvarial osteoblastic cells and mouse bone ma-row cells was established and cultured for 7 days. After the culture, staining for tartrateresistant ac´ol phosphatase, a marker enzyme of osteoclast, was executed and the number of tartrateresistant acid ´phosphatase positive multinucleated cells was counted. 1,25-dhydroxyvitamn D; and tumor necrosis factor a significantly stimulated the osteoclast formation. When 5lipoxygenase pathway was blocked by caffeic acid, 1,25dihydroxyvitamin D, or tumor ´necrosis
factor- a -induced osteoclast formation was significantly inhibited. Furthermore, when both cyclooxygenase and 54poxygenase pathway were blocked by combined treatment of indomethaoin and caffeic acid, 1,25dhydroxyvitamin D, o-tumor necrosis factor a -induced osteoclast formation was almost completely inhibited. Though phospholipase A, or meilitin failed to induce osteoclast formation- sy themselves, they significantly enhanced 1,25dihydroxyvitamin D:induced osteoclast formation. And caffeic acid partly , inh!Lted the osteoclast formation induced by comD´ned t7eatment of phospholipase A, and 125dihydroxyvitarrin D, or meliftur and 1,25dihydroxyvitamin D;. Taken toge her, 5lipoxygenase metabolites seem to have certain role(3) in the osteoc:ast formation induced by 1,25dihydroxyvitamin D; or tumor necrosis factora and in the local bone destruction associated with inflammation by enhancing osteoclast fDrmation. | en |
dc.language.iso | ko | en |
dc.publisher | 대한치과의사학회 | en |
dc.subject | 1,25-dihydroxyvitamin D₃ | en |
dc.subject | 5-Lipoxygenase metabolite | en |
dc.title | 5-Lipoxygenase 대사산물들이 파골세포 생성에 미치는 영향 | en |
dc.title.alternative | Effects of 5-Lipoxygenase Matabolites on the Osteoclast Fromation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김효진 | - |
dc.contributor.AlternativeAuthor | 백전화 | - |
dc.contributor.AlternativeAuthor | 김관식 | - |
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