Browse

Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2

Cited 32 time in Web of Science Cited 32 time in Scopus
Authors
Heo, Seong-Joo; Jang, Jun-Hyeog; Ku, Young; Chung, Chong-Pyoung
Issue Date
2002-10
Publisher
Springer Verlag
Citation
Biotechnology Letters. 24: 1659-1663.
Keywords
cell adhesionextracellular matrixFGF-2fibronectinsignal transduction
Abstract
Using specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways.
ISSN
0141-5492
Language
English
URI
https://hdl.handle.net/10371/47283
DOI
https://doi.org/10.1023/A:1020617904251
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse