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Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2

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dc.contributor.authorHeo, Seong-Joo-
dc.contributor.authorJang, Jun-Hyeog-
dc.contributor.authorKu, Young-
dc.contributor.authorChung, Chong-Pyoung-
dc.date.accessioned2010-02-01T06:04:27Z-
dc.date.available2010-02-01T06:04:27Z-
dc.date.issued2002-10-
dc.identifier.citationBiotechnology Letters. 24: 1659-1663.en
dc.identifier.issn0141-5492-
dc.identifier.urihttps://hdl.handle.net/10371/47283-
dc.description.abstractUsing specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectcell adhesionen
dc.subjectextracellular matrixen
dc.subjectFGF-2en
dc.subjectfibronectinen
dc.subjectsignal transductionen
dc.titleEnhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2en
dc.typeArticleen
dc.contributor.AlternativeAuthor허성주-
dc.contributor.AlternativeAuthor장준혁-
dc.contributor.AlternativeAuthor구영-
dc.contributor.AlternativeAuthor정종평-
dc.identifier.doi10.1023/A:1020617904251-
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