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두경부 편평세포암종세포주에서 retinoic acid가 linear-quadratic 모델을 적용한 방사선감수성과 apoptosis 유발에 미치는 영향 : The effect of retinoic acid on radiosensitivity analyzed by linear-quadratic model and apoptosis in head and neck squamous carcinoma cell lines
DC Field | Value | Language |
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dc.contributor.author | 이은숙 | - |
dc.contributor.author | 강범현 | - |
dc.contributor.author | 허민석 | - |
dc.contributor.author | 이삼선 | - |
dc.contributor.author | 최현배 | - |
dc.contributor.author | 최순철 | - |
dc.contributor.author | 박태원 | - |
dc.date.accessioned | 2010-02-01T06:09:33Z | - |
dc.date.available | 2010-02-01T06:09:33Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | 대한구강악안면방사선학회지 2001; 31 : 135-143. | en |
dc.identifier.issn | 1229-8212 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47386 | - |
dc.description.abstract | Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods: We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2, 4, 6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1,2, 3, 4 and 5 after irradiation (2, 10 and 20 Gy) combined with retinoic acid. Results and Conclusion: SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive. For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714 (NHOK), 4.098 (HEp-2) and 11.79 (FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis. | en |
dc.language.iso | ko | en |
dc.publisher | 대한구강악안면방사선학회 | en |
dc.subject | apoptosis | en |
dc.subject | retinoid | en |
dc.subject | radiation | en |
dc.subject | ionizing | en |
dc.subject | radiation tolerance | en |
dc.title | 두경부 편평세포암종세포주에서 retinoic acid가 linear-quadratic 모델을 적용한 방사선감수성과 apoptosis 유발에 미치는 영향 | en |
dc.title.alternative | The effect of retinoic acid on radiosensitivity analyzed by linear-quadratic model and apoptosis in head and neck squamous carcinoma cell lines | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | Lee, Eun-Sook | - |
dc.contributor.AlternativeAuthor | Kang, Bum-Hyun | - |
dc.contributor.AlternativeAuthor | Heo, Min-Suk | - |
dc.contributor.AlternativeAuthor | Lee, Sam-Sun | - |
dc.contributor.AlternativeAuthor | Choi, Hyun-Bae | - |
dc.contributor.AlternativeAuthor | Choi, Soon-Chul | - |
dc.contributor.AlternativeAuthor | Park, Tae-Won | - |
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