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Implant surface treatments affect gene expression of Runx2, osteogenic key marker

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dc.contributor.authorNa, Young-
dc.contributor.authorHeo, Seong-Joo-
dc.contributor.authorKim, Seong-Kyun-
dc.contributor.authorKoak, Jai-Young-
dc.date.accessioned2010-02-01T09:53:48Z-
dc.date.available2010-02-01T09:53:48Z-
dc.date.issued2009-
dc.identifier.citationThe Journal of Advanced Prosthodontics 2009;1(2)en
dc.identifier.urihttp://hdl.handle.net/10371/47846-
dc.description.abstractSTATEMENT OF PROBLEM. The aim of this study was to study the effects of various surface treatments to a titanium surface on the expression of Runx2 in vitro. MATERIAL AND METHODS. Human Osteosarcoma TE-85 cells were cultured on machined, sandblasted, or anodic oxidized cpTi discs. At various times of incubation, the cells were collected and then processed for the analysis of mRNA expression of Runx2 using reverse transcription-PCR. RESULTS. The expression pattern of Runx2 mRNA was differed according to the types of surface treatment. When the cells were cultured on the untreated control culture plates, the gene expression of Runx2 was not increased during the experiments. In the case of that the cells were cultured on the machined cpTI discs, the expression level was intermediate at the first day, but increased constitutively to day 5. In cells on sandblasted cpTi discs, the expression level was highest in the first day sample and the level was maintained to 5 days. In cells on anodized cpTi discs, the expression level increased rapidly to 3 days, but decreased slightly in the 5-th day sample. CONCLUSION. Different surface treatments may contribute to the regulation of osteoblast function by influencing the level of gene expression of key osteogenic factors.en
dc.language.isoenen
dc.publisher대한치과보철학회en
dc.subjectRunx2 (Cbfa1)en
dc.subjectgene expressionen
dc.subjectimplant surface treatmenten
dc.subjectsurface roughnessen
dc.subjectosteogenesisen
dc.titleImplant surface treatments affect gene expression of Runx2, osteogenic key markeren
dc.typeArticleen
dc.contributor.AlternativeAuthor나영-
dc.contributor.AlternativeAuthor허성주-
dc.contributor.AlternativeAuthor김성균-
dc.contributor.AlternativeAuthor곽재영-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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