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악하선-설하선 혼합타액내 주요 단백질에 대한 구강내 주요 균주의 부착 : Adhesion of Oral Pathogens to Human Submandibular-Sublingual Salivary Proteins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승우 | - |
dc.contributor.author | 정성창 | - |
dc.contributor.author | 김영구 | - |
dc.contributor.author | 고홍섭 | - |
dc.date.accessioned | 2010-02-01T09:58:43Z | - |
dc.date.available | 2010-02-01T09:58:43Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | 대한안면통증구강내과학회지 대한구강내과학회지, 24(3):235-244. | en |
dc.identifier.issn | 1225-0627 | - |
dc.identifier.uri | http://uci.or.kr/G300-j12250627.v24n3p235 | - |
dc.identifier.uri | https://hdl.handle.net/10371/47945 | - |
dc.description.abstract | The present study was performed to investigate the binding between salivary proteins(low-molecular-weight mucin;MG2, amylase, proline-rich protenis;PRPs) and oral pathogens(Streptococcus gorconii,Actinomyces viscosus, Staphylococcus) by using solid-phase assay.
In the case of transferring proteins to Immobilon-P,S. gordonii binds to MG2. A. viscosus binds to MG2, amylase, and PRPs, and S. aureus binds to MG2 and amylase. On nitrocellulose membrane, S. gordonii and A. viscosus bind to MG2, amylase, and PRPs. S. aureus binds to MG2 and PRPs. However, rabbit anti-A. viscosus antisera and rabbit anti-S. aureus antisera showed cross reactivity to PRPs adsorbed to only nitrocellulose membrane in negative control experiments, which were done without bacterial overlay. The results were different according to the membrane used as solid-phase, which reflected the assat-sensitive nature of binding experiment. PRPs and amylase are known to be comonents of tooth enamel pellicle. In addition, there was experimental evidence that PRPs and MG2 may covalently bind to oral mucosal epithelium. Considering above facts, the results of the present study can provide information on the interactions between salivary proteins and oral bacteria on tooth and oral mucoasl surfaces. | en |
dc.description.sponsorship | 서울대학교 일반연구비(04-1998-052-0) | en |
dc.language.iso | ko | en |
dc.publisher | 대한안면통증구강내과학회 | en |
dc.subject | saliva | en |
dc.subject | mucin | en |
dc.subject | amylase | en |
dc.subject | proline-rich | en |
dc.subject | proteins | en |
dc.subject | adhesion | en |
dc.subject | binding | en |
dc.subject | assay | en |
dc.title | 악하선-설하선 혼합타액내 주요 단백질에 대한 구강내 주요 균주의 부착 | en |
dc.title.alternative | Adhesion of Oral Pathogens to Human Submandibular-Sublingual Salivary Proteins | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | Lee, Sung-Woo | - |
dc.contributor.AlternativeAuthor | Chung, Sung-Chang | - |
dc.contributor.AlternativeAuthor | Kim, Young-Ku | - |
dc.contributor.AlternativeAuthor | Kho, Hong-Seop | - |
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