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Quantitative Study of Thymocytes Injected into Young. Rats born to Azathioprine-administered Pregnant Rats : 임신중 투여된 Azathioprine (Imuran)에 의해 면역기능이 억제된 신생흰쥐에 정주할 흉선세포의 정량에 관한 연구

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dc.contributor.authorChang, Ka Young-
dc.contributor.authorHwang, Young Il-
dc.contributor.authorLee, Wang Jae-
dc.contributor.authorCha, Choong Ik-
dc.contributor.authorCho, Sa Sun-
dc.contributor.authorSeoung, Key June-
dc.contributor.authorLee, Kwang Ho-
dc.date.accessioned2009-07-08T05:18:34Z-
dc.date.available2009-07-08T05:18:34Z-
dc.date.issued1985-03-
dc.identifier.citationSeoul J Med, Vol.26 No.1, pp. 1-7-
dc.identifier.issn0582-6802-
dc.identifier.urihttps://hdl.handle.net/10371/5328-
dc.description.abstractThe plaque assay was performed to determine the optimal dosage of thymus
cells to be inoculated into the neonatally T-cell depleted rats by azathioprine for the recovery
of immune function. The experimental animals were two hundred young rats which were born
to sixty normal Sprague-Dawley pregnant rats, of which 45 rats had 8 mg/kg of azathioprine
orally administered to them on the 7th day of the gestation. Sheep erythrocytes (sRBC)
antigen was intraperitioneally injected into the animals on the 4th & 8th weeks after birth and
simultaneously the thymus cells derived from outbred Sprague-Dawley rats were inoculated
into 4 experimental groups with the dosages of 105
, 106
, 107 and 108 thymus cells, respectively.
The spleens were resected on the 3rd & 7th days after sRBC injection for the plaque assay.
The following results were obtained.
1. In the neonatally T-cell depleted group, there was statistically significant decrease in
the number of PFC, compared with that in the control group.
2. In the 4 week old groups, the normal level of PFC could be reached by the inoculation
of between 106 and 107 thymus cells, in 8 week old groups, by the inoculation of between
105 & 106 thymus cells.
3. In both 4 week old and 8 week old groups, the peak numbers of PFC were obtained
by the inoculation of 107 thymus cells.
-
dc.language.isoen-
dc.publisherSeoul National University College of Medicine-
dc.subjectPlaque assay-
dc.subjectNeonatal T-cell depletion by azathioprine-
dc.subjectThymocyte inoculation-
dc.titleQuantitative Study of Thymocytes Injected into Young. Rats born to Azathioprine-administered Pregnant Rats-
dc.title.alternative임신중 투여된 Azathioprine (Imuran)에 의해 면역기능이 억제된 신생흰쥐에 정주할 흉선세포의 정량에 관한 연구-
dc.typeSNU Journal-
dc.contributor.AlternativeAuthor장가용-
dc.contributor.AlternativeAuthor황영일-
dc.contributor.AlternativeAuthor이왕재-
dc.contributor.AlternativeAuthor차중익-
dc.contributor.AlternativeAuthor조사선-
dc.contributor.AlternativeAuthor성기준-
dc.contributor.AlternativeAuthor이광호-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
dc.citation.endpage7-
dc.citation.number1-
dc.citation.pages1-7-
dc.citation.startpage1-
dc.citation.volume26-
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