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Quantitative Study of Thymocytes Injected into Young. Rats born to Azathioprine-administered Pregnant Rats : 임신중 투여된 Azathioprine (Imuran)에 의해 면역기능이 억제된 신생흰쥐에 정주할 흉선세포의 정량에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | Chang, Ka Young | - |
dc.contributor.author | Hwang, Young Il | - |
dc.contributor.author | Lee, Wang Jae | - |
dc.contributor.author | Cha, Choong Ik | - |
dc.contributor.author | Cho, Sa Sun | - |
dc.contributor.author | Seoung, Key June | - |
dc.contributor.author | Lee, Kwang Ho | - |
dc.date.accessioned | 2009-07-08T05:18:34Z | - |
dc.date.available | 2009-07-08T05:18:34Z | - |
dc.date.issued | 1985-03 | - |
dc.identifier.citation | Seoul J Med, Vol.26 No.1, pp. 1-7 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5328 | - |
dc.description.abstract | The plaque assay was performed to determine the optimal dosage of thymus
cells to be inoculated into the neonatally T-cell depleted rats by azathioprine for the recovery of immune function. The experimental animals were two hundred young rats which were born to sixty normal Sprague-Dawley pregnant rats, of which 45 rats had 8 mg/kg of azathioprine orally administered to them on the 7th day of the gestation. Sheep erythrocytes (sRBC) antigen was intraperitioneally injected into the animals on the 4th & 8th weeks after birth and simultaneously the thymus cells derived from outbred Sprague-Dawley rats were inoculated into 4 experimental groups with the dosages of 105 , 106 , 107 and 108 thymus cells, respectively. The spleens were resected on the 3rd & 7th days after sRBC injection for the plaque assay. The following results were obtained. 1. In the neonatally T-cell depleted group, there was statistically significant decrease in the number of PFC, compared with that in the control group. 2. In the 4 week old groups, the normal level of PFC could be reached by the inoculation of between 106 and 107 thymus cells, in 8 week old groups, by the inoculation of between 105 & 106 thymus cells. 3. In both 4 week old and 8 week old groups, the peak numbers of PFC were obtained by the inoculation of 107 thymus cells. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Plaque assay | - |
dc.subject | Neonatal T-cell depletion by azathioprine | - |
dc.subject | Thymocyte inoculation | - |
dc.title | Quantitative Study of Thymocytes Injected into Young. Rats born to Azathioprine-administered Pregnant Rats | - |
dc.title.alternative | 임신중 투여된 Azathioprine (Imuran)에 의해 면역기능이 억제된 신생흰쥐에 정주할 흉선세포의 정량에 관한 연구 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 장가용 | - |
dc.contributor.AlternativeAuthor | 황영일 | - |
dc.contributor.AlternativeAuthor | 이왕재 | - |
dc.contributor.AlternativeAuthor | 차중익 | - |
dc.contributor.AlternativeAuthor | 조사선 | - |
dc.contributor.AlternativeAuthor | 성기준 | - |
dc.contributor.AlternativeAuthor | 이광호 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 7 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 1-7 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 26 | - |
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