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The Effect of pH on Na-Ca Exchange In Atrial Myocytes of Rabbit : 토끼 심방근세포에서 pH가 Na-Ca 교환기전에 미치는 영향
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- Authors
- Issue Date
- 1989-09
- Citation
- Seoul J Med, Vol.30 No.3, pp. 149-156
- Keywords
- Na-Ca exchange ; Na-free contracture ; pH ; Rabbit atrium
- Abstract
- In atrial trabeculae and single atrial cells, we examined the effect of pH on the
Na-Ca exchange mechanism. In atrial trabeculae both acidic and alkaline pH reduced Na-free
contracture. Inward current of Na-Ca exchange activated by repolarizing pulse after a brief
depolarizing pulse to +40 mV for 2 ms from the holding potential of -70 mV in single atrial
cells was reduced by acidic pH, and enhanced by alkaline pH. Amiloride, which causes
intracellular acidosis, reduced Na-Ca exchange current and 20 mM NH4CI {intracellular
alkalosis}-enhanced Na-Ca exchange current. From the above results, it was concluded that
the effect of pH on forward and reverse modes of Na-Ca exchange might not be symmetric.
- ISSN
- 0582-6802
- Language
- English
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