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The Effect of pH on Na-Ca Exchange In Atrial Myocytes of Rabbit
토끼 심방근세포에서 pH가 Na-Ca 교환기전에 미치는 영향

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Authors
So, Insuk; Earm, Yung E; Kim, Jun; Hwang, Sang Ik; Ho, Won Kyung; Kim, Eui Yang; Ahn, Cheal Soo; Park, Choon Ok
Issue Date
1989-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.30 No.3, pp. 149-156
Keywords
Na-Ca exchangeNa-free contracturepHRabbit atrium
Abstract
In atrial trabeculae and single atrial cells, we examined the effect of pH on the
Na-Ca exchange mechanism. In atrial trabeculae both acidic and alkaline pH reduced Na-free
contracture. Inward current of Na-Ca exchange activated by repolarizing pulse after a brief
depolarizing pulse to +40 mV for 2 ms from the holding potential of -70 mV in single atrial
cells was reduced by acidic pH, and enhanced by alkaline pH. Amiloride, which causes
intracellular acidosis, reduced Na-Ca exchange current and 20 mM NH4CI {intracellular
alkalosis}-enhanced Na-Ca exchange current. From the above results, it was concluded that
the effect of pH on forward and reverse modes of Na-Ca exchange might not be symmetric.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5551
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 30 No.3 (1989)
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