S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 34 No.3 (1993)
Sarcomatoid Renal Cell Carcinoma with an Unusually Rapid Fatal Course
- Oh, Young Lyun; Kim, Woo Ho; Chi, Je G.
- Issue Date
- Seoul J Med, Vol.34 No.3, pp. 223-227
- Sarcomatoid renal cell carcinoma is an uncommon neoplasm consisting
of typical renal cell carcinoma associated intimately with a sarcomatoid
component. The prognosis is known to be very poor. We present an autopsy case
of sarcomatoid renal cell carcinoma that went through a highly fulminant lethal
course. The patient was a 62-year-old male with left flank pain and weight loss.
Computed tomograph and aortogram revealed a left renal mass growing out into
the retroperitoneum. Multiple metastatic nodules were detected in the lungs and
bone. Histologically the tumor showed features of anaplastic carcinoma, malignant
fibrous histiocytoma and fibrosarcoma. Immunohistochemical studies of
tumor revealed positive staining for cytokeratin (CAM 5.2). We interpreted this
tumor as a sarcomatoid renal cell carcinoma extending into the retroperitoneum.
He died of respiratory failure secondary to massive lung and mediastinal involvement
of the tumor masses.