S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 34 No.1 (1993)
ChiIdhood GIioblastoma Multiforme Mimicking BasaI Meningitis -Report of An Autopsy Case-
- Song, Sang Yong; Chi, Je G.
- Issue Date
- Seoul J Med, Vol.34 No.1, pp. 63-67
- Glioblastoma multiforme; Childhood; Thalamus; Hypothalamus; Brainstem; Meningitis; Leptomeningeal spread
- Glioblastoma multiforme is a highly malignant neuroglial tumor
rarely reported in children with several differences compared to the adult tumor.
Its clinical diagnosis is sometimes difficult because most children do not have an
antecedant history to herald the development of the tumor. We report a case of
glioblastoma multiforme in a child that presented clinically and radiologically as a
tuberculous basal meningitis, and turned out to be a glioblastoma multiforme
involving the thalamus, hypothalamus and brainstem, and spreading massively
through the leptomeningeal and ventricular spaces. A 6-year-old girl presented
with non-projectile vomiting and mild fever on October 1990. Over the ensuing 6
months she was found to have hydrocephalus and blurring of vision. She was
treated for possible tuberculous meningitis without any improvement. Repeated
CSF smears, cultures, cytology and brain CT did not provide any clue to a
specific diagnosis. She remained stationary until January 23, 1992 when she
elappsed into coma at home and died after supportive management for 7 days.
Postmortem examination showed widespread gray white coating or nodules over
the cerebellar and cerebral convexities as well as the brain base. Serial sections
revealed that the main lesion was located in the thalamus, hypothalamus, and
brainstem. Microscopically, it was a glioblastoma multiforme consisting
predominantly of anaplastic spindle cells.