Publications
Detailed Information
Age-Related Changes In Ouabain Pharmacokinetics : Ouabain 약력학적 성질의 연령에 따른 변화
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Sang-Goo | - |
dc.contributor.author | Park, Chan-Woong | - |
dc.contributor.author | Lee, Kwang-Soo | - |
dc.date.accessioned | 2009-07-17T04:08:57Z | - |
dc.date.available | 2009-07-17T04:08:57Z | - |
dc.date.issued | 1985-03 | - |
dc.identifier.citation | Seoul J Med, Vol.26 No.1, pp. 33-40 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5666 | - |
dc.description.abstract | Young animals and humans frequently require higher doses of digitalis glycoside
per kilogram of body weight or per square meter of body surface area than adult to induce the digitalis effect or toxicity. In order to investigate the pharmacokinetic basis for this observation, we studied pharmacokinetic properties of the relatively polar and rapidly acting cardiac glycoside, ouabain, in adult and young rabbits. Consistent with reported observations, we found no significant difference in transfer coefficients in a linear two compartmental open model for ouabain pharmacokinetics following a 0.05 mg/kg bolus. However, we found that young rabbits had larger ouabain volume of distribution per kilogram of body weight than adults (Vc; 274.36±24.24(S.E.) mllkg vs. 138.29±7.51, Vdss; 1580.61±75.77 mllkg vs. 1056.01±88.18, p<0.005), and a larger systemic clearance (9.18±0.74 mllkg/min vs. 4.67 ±0.80, Pnearly twice the serum concentrations at the same dose per kilogram, throughout the experimental period. Left and right ventricular ouabain concentrations were inversely related to the volumes of distribution, with significantly higher tissue levels in adult animals. Although the reason for the difference of tissue sensitivity to a given digitalis glycoside concentration remains unclear, the result of this study suggests that the pharmacokinetic difference is responsible for age-related tolerance to digitalis glycoside doses. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Ouabain | - |
dc.subject | Digitalis glycoside | - |
dc.subject | Rabbits | - |
dc.subject | Pharmacokinetics | - |
dc.subject | Two-compartment model | - |
dc.subject | Serum level | - |
dc.subject | Urinary excretion | - |
dc.subject | Age- related changes | - |
dc.subject | Mechanism of tolerance | - |
dc.title | Age-Related Changes In Ouabain Pharmacokinetics | - |
dc.title.alternative | Ouabain 약력학적 성질의 연령에 따른 변화 | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.contributor.AlternativeAuthor | 박찬웅 | - |
dc.contributor.AlternativeAuthor | 이광수 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 40 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 33-40 | - |
dc.citation.startpage | 33 | - |
dc.citation.volume | 26 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.