S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 28 No.1 (1987)
Evidence of a Hepadna Virus Infection in Manchurian Chipmunks
한국산 다람쥐에서의 Hepadna virus 감염
- Yoo, Byung Chul; Kim, Chung Yong
- Issue Date
- Seoul J Med, Vol.28 No.1, pp. 16-21
- In attempting to find a new host of hepadna virus, sera of Manchurian chipmunks
(Tamias sibiricus asiaticus ) were tested for serologic markers of hepatitis B virus and virus like
Of 47 tested animals, HBsAg reactivities were found in sera of 6 animals and anti-HBs in 7
animals by radioimmunoassay. The HBsAg-positive sera were examined by electron microscopy.
Numerous spherical particles 21 nm in diameter and many spherical double-shelled
particles 41 nm in diameter, which look similar to Dane particles, were observed in all the
The amount of 41 nm particles seems to correlate with the titer of HBsAg reactivities.
Histologic examination of liver tissues from the HBsAg and particles-positive animals showed
no evidence of liver disease.
The detection of HBsAg reactivities and particles similar in appearance to the particles of
hepatitis B virus in sera of Manchurian chipmunks strongly suggests infection of a hepadna
virus in these animals.