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Surgical management of mechanical valve thrombosis: twenty-six years' experience

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Ahn, Hyuk; Kim, Kyung-Hwan; Kim, Kwan Chang; Kim, Chang Young
Issue Date
2008-06-28
Publisher
Korean Academy of Medical Sciences
Citation
J Korean Med Sci. 2008 Jun;23(3):378-82.
Keywords
AdultAgedAnticoagulants/therapeutic useCoronary Thrombosis/drug therapy/*mortality/*surgeryDrug InteractionsFemaleFollow-Up StudiesHeart Valve Prosthesis/*adverse effects/*statistics & numerical dataHeparin/therapeutic useHumansInternational Normalized RatioMaleMiddle AgedPatient CompliancePostoperative Complications/drug therapy/*mortality/*surgeryPregnancyPregnancy Complications/mortalityRecurrenceReoperation/statistics & numerical dataRetrospective StudiesRisk FactorsThrombolytic TherapyWarfarin/therapeutic use
Abstract
In the present study, the authors investigated the management of mechanical valve thrombosis (MVT). From January 1981 through March 2006, 2,908 mechanical valve replacements were performed in 2,298 patients at our institution. Twenty (0.87%) patients presented with MVT, 14 (70.0%) were women, and the mean age of the patients was 42.0+/-14.0 (27-66) yr. Thrombosis involved mitral in 14 (70.0%), aortic in 2 (10.0%), tricuspid/aortic in 1 (5%), and tricuspid in 3 (15%). The interval from first operation to valve thrombosis was 121.8+/-75.4 (0.9-284.7) months. The most frequent clinical presentation was heart failure (13/20, 65%), and predisposing causes of MVT were: poor compliance with warfarin (7), pregnancy (5), drug interaction (2), and unknown (6). All 20 patients underwent valve replacement: mitral (14, 70.0%), tricuspid (3, 15.0%), aortic (2, 10%) and tricuspid/aortic (1, 5%). One early death occurred due to left ventricular failure, but no late mortality occurred during 63.3+/-49.9 (0.5-165.1) months of follow-up. MVT was treated successfully, and pregnancy and inadequate anticoagulation were found to influence the occurrence of this rare complication.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18583870

http://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-23-378.pdf

https://hdl.handle.net/10371/60094
DOI
https://doi.org/10.3346/jkms.2008.23.3.378
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College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
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