Browse

Dibenzocyclooctadiene Lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity

Cited 78 time in Web of Science Cited 91 time in Scopus
Authors
Kim, So Ra; Lee, Mi Kyeong; Koo, Kyung Ah; Kim, Seung Hyun; Sung, Sang Hyun; Lee, Na Gyong; Markelonis, George J.; Oh, Tae H.; Yang, Jae Ho; Kim, Young Choong
Issue Date
2004
Publisher
Wiley-Blackwell
Citation
Journal of Neuroscience Research 76:397–405
Keywords
dibenzocyclooctadiene lignansexcitotoxic cell damageglutathione defense systemneuroprotective activitySchisandra chinensis
Abstract
A methanolic extract of dried Schisandra fruit (Schisandra
chinensis Baill.; Schisandraceae) significantly attenuated
the neurotoxicity induced by L-glutamate in primary cultures
of rat cortical cells. Five dibenzocyclooctadiene lignans
(deoxyschisandrin, gomisin N, gomisin A, schisandrin,
and wuweizisu C) were isolated from the methanolic extract;
their protective effects against glutamate-induced
neurotoxicity were then evaluated. Among the five lignans,
deoxyschisandrin, gomisin N, and wuweizisu C significantly
attenuated glutamate-induced neurotoxicity as measured
by 1) an inhibition in the increase of intracellular [Ca2 ]; 2)
an improvement in the glutathione defense system, the
level of glutathione, and the activity of glutathione peroxidase;
and 3) an inhibition in the formation of cellular peroxide.
These results suggest that dibenzocyclooctadiene lignans
from Schisandra chinensis may possess therapeutic
potential against oxidative neuronal damage induced by
excitotoxin.
ISSN
0360-4012
Language
English
URI
https://hdl.handle.net/10371/62031
DOI
https://doi.org/10.1002/jnr.20089
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse