S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures.
- Sauvageot, Claire; Dahia, Patricia L.; Lipan, Ovidiu; Park, John K.; Chang, Mi-Sook; Alberta, John A.; Stiles, Charles D.
- Issue Date
- Wiley Periodicals
- Journal of Neurobiology, Vol.62 No.1 pp. 121–133
- Cortical progenitor cells from rat embryos give rise to neurons or glia following exposure to platelet derived growth factor (PDGF) or ciliary neurotrophic factor (CNTF), respectively. Both growth factors impart their developmental cues quickly through a transcription-dependent mechanism. Do the alternate developmental responses to PDGF and CNTF reflect induction of qualitatively distinct genes? Alternatively, do the same genes respond to each growth factor, but with quantitatively distinct kinetics? Using differential library screening and custom cDNA microarrays we show that a common set of genes responds to either growth factor. However, quantitative differences in the onset and duration of gene induction equate to the expression of factor-specific gene signatures. Multitissue cluster analysis also reveals tissue-specific gene signatures that may play important roles in the developing brain.
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