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Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sauvageot, Claire | - |
dc.contributor.author | Dahia, Patricia L. | - |
dc.contributor.author | Lipan, Ovidiu | - |
dc.contributor.author | Park, John K. | - |
dc.contributor.author | Chang, Mi-Sook | - |
dc.contributor.author | Alberta, John A. | - |
dc.contributor.author | Stiles, Charles D. | - |
dc.date.accessioned | 2010-03-29T04:40:12Z | - |
dc.date.available | 2010-03-29T04:40:12Z | - |
dc.date.issued | 2005-01 | - |
dc.identifier.citation | Journal of Neurobiology, Vol.62 No.1 pp. 121–133 | en |
dc.identifier.issn | 1932-8451(print) | - |
dc.identifier.issn | 1932-846X(online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62077 | - |
dc.description.abstract | Cortical progenitor cells from rat embryos give rise to neurons or glia following exposure to platelet derived growth factor (PDGF) or ciliary neurotrophic factor (CNTF), respectively. Both growth factors impart their developmental cues quickly through a transcription-dependent mechanism. Do the alternate developmental responses to PDGF and CNTF reflect induction of qualitatively distinct genes? Alternatively, do the same genes respond to each growth factor, but with quantitatively distinct kinetics? Using differential library screening and custom cDNA microarrays we show that a common set of genes responds to either growth factor. However, quantitative differences in the onset and duration of gene induction equate to the expression of factor-specific gene signatures. Multitissue cluster analysis also reveals tissue-specific gene signatures that may play important roles in the developing brain. | en |
dc.description.sponsorship | Contract grant sponsor: NIH; contract grant numbers: PO1
HD24926-12 (C.D.S) and RO1 HG02341 (O.L.). Contract grant sponsor: Dana Foundation (C.D.S.). Contract grant sponsor: Claudia Adams Barr Investigatorship (P.L.D.). | en |
dc.language.iso | en | en |
dc.publisher | Wiley Periodicals | en |
dc.subject | cortical stem cells | en |
dc.subject | differentiation | en |
dc.subject | expression analysis | en |
dc.subject | growth factors | en |
dc.title | Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. | en |
dc.type | Article | en |
dc.author.alternative | 장미숙 | - |
dc.identifier.doi | 10.1002/neu.20072 | - |
dc.citation.journaltitle | Journal of Neurobiology | - |
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