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High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea

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dc.contributor.authorPark, Su Cheol-
dc.contributor.authorJeong, Sook-Hyang-
dc.contributor.authorKim, Jin-
dc.contributor.authorHan, Chul Ju-
dc.contributor.authorKim, You Cheoul-
dc.contributor.authorChoi, Kui Sung-
dc.contributor.authorCho, Jang Hyun-
dc.contributor.authorLee, Myoungjin-
dc.contributor.authorJung, Ha Hyun-
dc.contributor.authorKi, Seung Seog-
dc.contributor.authorChang, Yoon Hwan-
dc.contributor.authorLee, Seung Sook-
dc.contributor.authorPark, Yeon Hee-
dc.contributor.authorLee, Kee Ho-
dc.date.accessioned2010-03-31T05:37:06Z-
dc.date.available2010-03-31T05:37:06Z-
dc.date.issued2008-04-23-
dc.identifier.citationJ Med Virol. 2008 ;80(6):960-6.en
dc.identifier.issn0146-6615 (Print)-
dc.identifier.urihttps://hdl.handle.net/10371/62199-
dc.description.abstractThis study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non-Hodgkin's lymphoma.en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDNA, Viral/analysisen
dc.subjectFemaleen
dc.subjectGenes, Viral/geneticsen
dc.subjectHepatitis B/*complications/*epidemiologyen
dc.subjectHepatitis B Core Antigens/analysisen
dc.subjectHepatitis B Surface Antigens/analysisen
dc.subjectHepatitis B virus/genetics/isolation & purificationen
dc.subjectHepatitis C/epidemiologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKorea/epidemiologyen
dc.subjectLeukocytes, Mononuclear/virologyen
dc.subjectLymphoma, B-Cell/*complications/epidemiology/virologyen
dc.subjectLymphoma, Non-Hodgkin/*complications/epidemiology/virologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectStomach Neoplasms/complications/epidemiologyen
dc.titleHigh prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor박수철-
dc.contributor.AlternativeAuthor정숙향-
dc.contributor.AlternativeAuthor김진-
dc.contributor.AlternativeAuthor한철주-
dc.contributor.AlternativeAuthor김유철-
dc.contributor.AlternativeAuthor최귀성-
dc.contributor.AlternativeAuthor조장현-
dc.contributor.AlternativeAuthor이명진-
dc.contributor.AlternativeAuthor정하현-
dc.contributor.AlternativeAuthor기승석-
dc.contributor.AlternativeAuthor장윤환-
dc.contributor.AlternativeAuthor이승숙-
dc.contributor.AlternativeAuthor박연희-
dc.contributor.AlternativeAuthor이기호-
dc.identifier.doi10.1002/jmv.21168-
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