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Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, S. H. | - |
dc.contributor.author | Cho, Y. M. | - |
dc.contributor.author | Moon, M. K. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Park, B. L. | - |
dc.contributor.author | Cheong, H. S. | - |
dc.contributor.author | Shin, H. D. | - |
dc.contributor.author | Jang, H. C. | - |
dc.contributor.author | Kim, S. Y. | - |
dc.contributor.author | Lee, H. K. | - |
dc.contributor.author | Park, K. S. | - |
dc.date.accessioned | 2010-03-31T07:26:22Z | - |
dc.date.available | 2010-03-31T07:26:22Z | - |
dc.date.issued | 2007-10-05 | - |
dc.identifier.citation | Diabetes Res Clin Pract. 2008 ;79(2):284-90. | en |
dc.identifier.issn | 1872-8227 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62234 | - |
dc.description.abstract | Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus. Several genetic association studies examined IDE as a susceptibility gene for type 2 diabetes in European descents. Here we investigated the genetic association of IDE polymorphisms with the risk of type 2 diabetes and its related phenotypes in the Korean population. Among six single nucleotide polymorphisms analyzed, g.-179T>C (OR=1.73, P=0.04), and g.IVS18+99G>A (OR=1.23, P=0.02) revealed borderline association with increased risk of type 2 diabetes. Combining our results with previous data obtained from the European population, g.-179T>C (OR=1.11, P=0.03), and g.IVS24-64A>T (OR=1.18, P=0.005) showed significant association with type 2 diabetes. Haplotype consisting of common alleles of the six polymorphisms was associated with decreased risk of type 2 diabetes (OR=0.82, P=0.02). However, none of the polymorphisms was significantly associated with metabolic phenotypes. We can conclude that variations in IDE might contribute to diabetes susceptibility in the Korean population. | en |
dc.description.sponsorship | This work was supported by a grant from the Korea Health 21R&D Project, Ministry of Health & Welfare, Republic of Korea(00-PJ3-PG6-GN07-001). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Aged | en |
dc.subject | Chromosome Mapping | en |
dc.subject | Diabetes Mellitus, Type 2/enzymology/epidemiology/*genetics | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genetic Variation | en |
dc.subject | Humans | en |
dc.subject | Insulysin/*genetics | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Reference Values | en |
dc.subject | Risk Assessment | en |
dc.subject | Chromosomes, Human, Pair 10 | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population | en |
dc.type | Article | en |
dc.identifier.doi | 10.1016/j.diabres.2007.08.017 | - |
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