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A Study on Selective Cerebellar Degeneration Following ,β-Fluorethyl Acetate Poisoning

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Authors
Jeon, Beom Seok; Na, Duk Lyul; Park, Sung Ho; Lee, Kwang Woo; Roh, Jae Kyu; Lee, Sang Bok; Myung, Ho Jin; Chang, Kee Hyun
Issue Date
1992-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.33 No.3, pp. 195-202
Keywords
β-fluoroethyl acetateFluoroacetateCerebellar degeneration
Abstract
This is to report clinical and radiological findings in 7 patients with selective
cerebellar degeneration following ,B-fluoroethyl acetate intoxication. ,B-Fluoroethyl
acetate, an ethyl ester of fluoroacetate which is a metabolic inhibitor of Krebs cycle is
used as a rodenticide. Following initial stage of coma from intoxication, the patients
woke up to show selective cerebellar dysfunction, often so severe as not to be able to sit
or stand unsupported. They improved gradually over several months to years with variable
degrees of residual cerebellar dysfunction. Gait disturbance and dysarthria were
the most prominent and persistent factors of the cerebellar dysfunction, whereas mild
nystagmus was rarely seen. Cognitive function was not impaired. Cerebellar atrophy
became noticeable on CT and MRI 4 weeks after poisoning, and progressed over time
even with clinical improvement. Cerebellar degeneration contrasts with pallidal degeneration
following carbon monoxide poisoning. ,B-Fluoroethyl acetate may be
selectively toxic to the cerebellum.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6237
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 33 No.3 (1992)
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