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Chlorhexidine Gluconate Attenuates the Ability of Lipoteichoic Acid from Enterococcus faecalis to Stimulate Toll-like Receptor 2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jin-Kyung | - |
dc.contributor.author | Baik, Jung Eun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Lee, WooCheol | - |
dc.contributor.author | Bae, Kwang-Shik | - |
dc.contributor.author | Baek, Seung-Ho | - |
dc.contributor.author | Lee, Yoon | - |
dc.contributor.author | Son, Won-Jun | - |
dc.contributor.author | Kum, Kee-Yeon | - |
dc.date.accessioned | 2010-04-02 | - |
dc.date.available | 2010-04-02 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | J Endod 2009;35:212–215 | en |
dc.identifier.issn | 0099-2399 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62381 | - |
dc.description.abstract | Chlorhexidine gluconate (CHX) has been widely used as a canal irrigant or an intracanal medicament on account of its antibacterial substantivity. This in vitro study aimed to determine if CHX attenuates the inflammatory activity of Enterococcus faecalis and its major virulence factor, lipoteichoic acid (LTA). An enzyme-linked immunosorbent assay showed that CHX-killed E. faecalis was less potent than heat-killed E. faecalis in the production of tumor necrosis factor α (TNF-α) by a murine macrophage cell line, RAW 264.7 (p < 0.05). Interestingly, pretreatment of LTA with 2% CHX for 6 hours or with 0.2% CHX for 24 hours almost eliminated the TNF-α inducibility (p < 0.05). Furthermore, CHX abrogated the ability of LTA to stimulate Toll-like receptor 2, resulting in the attenuated induction of TNF-α expression. Collectively, our results suggest that CHX can inactivate LTA of E. faecalis leading to the alleviation of inflammatory responses induced by E. faecalis and its LTA. | en |
dc.description.sponsorship | Supported by the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-314-E00223) and by a grant (03-2007-0090) from the Seoul National University Dental Hospital Research Fund, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | lipoteichoic acid | en |
dc.subject | Enterococcus faecalis | en |
dc.subject | Chlorhexidine gluconate | en |
dc.subject | tumor necrosis factor-α | en |
dc.subject | intracanal medicament | en |
dc.subject | Toll-like receptor 2 | en |
dc.title | Chlorhexidine Gluconate Attenuates the Ability of Lipoteichoic Acid from Enterococcus faecalis to Stimulate Toll-like Receptor 2 | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이진경 | - |
dc.contributor.AlternativeAuthor | 백정은 | - |
dc.contributor.AlternativeAuthor | 윤철희 | - |
dc.contributor.AlternativeAuthor | 이강석 | - |
dc.contributor.AlternativeAuthor | 한승현 | - |
dc.contributor.AlternativeAuthor | 이원철 | - |
dc.contributor.AlternativeAuthor | 배광식 | - |
dc.contributor.AlternativeAuthor | 백승호 | - |
dc.contributor.AlternativeAuthor | 이윤 | - |
dc.contributor.AlternativeAuthor | 손원준 | - |
dc.contributor.AlternativeAuthor | 금기연 | - |
dc.identifier.doi | 10.1016/j.joen.2008.10.018 | - |
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