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Mechanosensitivity of voltage-gated K+ currents in rat trigeminal ganglion neurons.
DC Field | Value | Language |
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dc.contributor.author | Piao, Lin | - |
dc.contributor.author | Li, Hai Ying | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Piao, Zheng Gen | - |
dc.contributor.author | Jung, Sung Jun | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.contributor.author | Park, Kyungpyo | - |
dc.contributor.author | Kim, Joong-Soo | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Choi, Se-Young | - |
dc.date.accessioned | 2010-04-09T04:51:26Z | - |
dc.date.available | 2010-04-09T04:51:26Z | - |
dc.date.issued | 2006-02 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE RESEARCH 83:1373-1380. | en |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62823 | - |
dc.description.abstract | We investigated the mechanosensitivity of voltage-gated K+ channel (VGPC) currents by using whole-cell patch clamp recording in rat trigeminal ganglion (TG) neurons. On the basis of biophysical and pharmacological properties, two types of VGPC currents were isolated. One was transient (IK,A), the other sustained (IK,V). Hypotonic stimulation (200 mOsm) markedly increased both IK,A and IK,V without affecting their activation and inactivation kinetics. Gadolinium, a well-known blocker of mechanosensitive channels, failed to block the enhancement of IK,A and IK,V induced by hypotonic stimulation. During hypotonic stimulation, cytochalasin D, an actin-based cytoskeletal disruptor, further increased IK,A and IK,V, whereas phalloidin, an actin-based cytoskeletal stabilizer, reduced IK,A and IK,V. Confocal imaging with Texas red-phalloidin showed that actin-based cytoskeleton was disrupted by hypotonic stimulation, which was similar to the effect of cytochalasin D. Our results suggest that both IK,A and IK,V are mechanosensitive and that actin-based cytoskeleton is likely to regulate the mechanosensitivity of VGPC currents in TG neurons. © 2006 Wiley-Liss, Inc. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | mechanosensitivity | en |
dc.subject | voltage-gated K+ currents | en |
dc.subject | trigeminal ganglion neuron | en |
dc.subject | hypotonic stimulation | en |
dc.subject | actin | en |
dc.subject | cytoskeleton | en |
dc.title | Mechanosensitivity of voltage-gated K+ currents in rat trigeminal ganglion neurons. | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박철규 | - |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 정성준 | - |
dc.contributor.AlternativeAuthor | 이성준 | - |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 김중수 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.identifier.doi | 10.1002/jnr.20810 | - |
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