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Effects of bisphenol A on breast cancer and its risk factors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Mihi | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Jeon, Raok | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.date.accessioned | 2010-04-13 | - |
dc.date.available | 2010-04-13 | - |
dc.date.issued | 2008-10-10 | - |
dc.identifier.citation | Arch Toxicol. 2009 ;83(3):281-5. | en |
dc.identifier.issn | 1432-0738 (Electronic) | - |
dc.identifier.issn | 0340-5761 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/63022 | - |
dc.description.abstract | The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 microg/L) and 13.87 microg/L (mean +/- SD, 1.69 +/- 2.57 microg/L; median, 0.043 microg/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer. | en |
dc.description.sponsorship | This work was supported by the SRC program of KOSEF (Research Center for Women's Diseases). | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Breast Neoplasms/*etiology | en |
dc.subject | Case-Control Studies | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Endocrine Disruptors/blood/*pharmacology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Phenols/blood/*pharmacology | en |
dc.subject | Risk Factors | en |
dc.title | Effects of bisphenol A on breast cancer and its risk factors | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 양미희 | - |
dc.contributor.AlternativeAuthor | 류재하 | - |
dc.contributor.AlternativeAuthor | 전라옥 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.identifier.doi | 10.1007/s00204-008-0364-0 | - |
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