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Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung Chan | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Choi, Seong Wook | - |
dc.contributor.author | Kim, Jeong Chul | - |
dc.contributor.author | Lim, Ki Moo | - |
dc.contributor.author | Kim, Kyuseok | - |
dc.contributor.author | Jung, Sung Koo | - |
dc.contributor.author | Kwak, Young Ho | - |
dc.contributor.author | Shin, Sang Do | - |
dc.contributor.author | Jo, Ik Joon | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Min, Byoung Goo | - |
dc.date.accessioned | 2010-04-13T01:17:42Z | - |
dc.date.available | 2010-04-13T01:17:42Z | - |
dc.date.issued | 2008-07-22 | - |
dc.identifier.citation | Artif Organs. 2008 ;32(7):541-6. | en |
dc.identifier.issn | 1525-1594 (Electronic) | - |
dc.identifier.issn | 0160-564X (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/63040 | - |
dc.description.abstract | This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device. | en |
dc.description.sponsorship | This study was supported by the grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Korea (02-PJ3-PG6-EV09-0001). | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Animals | en |
dc.subject | Charcoal/therapeutic use | en |
dc.subject | Dogs | en |
dc.subject | Hemodynamics | en |
dc.subject | Hemolysis | en |
dc.subject | Hemoperfusion/*instrumentation | en |
dc.subject | Paraquat/*blood/*poisoning | en |
dc.subject | Pulsatile Flow | en |
dc.subject | Heart-Assist Devices | - |
dc.title | Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정찬 | - |
dc.contributor.AlternativeAuthor | 박찬영 | - |
dc.contributor.AlternativeAuthor | 최성욱 | - |
dc.contributor.AlternativeAuthor | 김정철 | - |
dc.contributor.AlternativeAuthor | 임기무 | - |
dc.contributor.AlternativeAuthor | 김규석 | - |
dc.contributor.AlternativeAuthor | 정성구 | - |
dc.contributor.AlternativeAuthor | 곽영호 | - |
dc.contributor.AlternativeAuthor | 신상도 | - |
dc.contributor.AlternativeAuthor | 조익준 | - |
dc.contributor.AlternativeAuthor | 서길준 | - |
dc.contributor.AlternativeAuthor | 민병구 | - |
dc.identifier.doi | 10.1111/j.1525-1594.2008.00582.x | - |
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