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Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeonju | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Ha, Eun Hee | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Kang, Daehee | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.date.accessioned | 2010-04-13T01:24:53Z | - |
dc.date.available | 2010-04-13T01:24:53Z | - |
dc.date.issued | 2009-02-05 | - |
dc.identifier.citation | Cancer Epidemiol Biomarkers Prev. 2009;18(2):508-15. | en |
dc.identifier.issn | 1055-9965 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/63045 | - |
dc.description.abstract | High-density lipoprotein cholesterol (HDL-C) has been suggested to be associated with breast cancer. However, the roles of HDL-C and hypertriglyceridemia on breast cancer still have been controversial. The goal of this study was to investigate the association between HDL-C with breast cancer risk, stratifying by menopausal status, and body mass index. The hormonal receptor status of breast has been proposed to modify the effect of HDL-C on breast cancer. Multicenter hospital-based case-control study was conducted from November 2004 to December 2005 in Korea. After one to two individual matchings by age (+/-5 years) and menopausal status, 690 cases and 1,380 controls were included in the analysis. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by conditional, unconditional, and multinomial logistic regressions. Protective effect of HDL-C on breast cancer was only observed among premenopausal women with an OR (95% CI) of 0.49 (0.33-0.72) for HDL-C > or = 60 versus <50 mg/dL (P(trend) < 0.01). Only nonobese premenopausal women had a significant decreased risk (OR, 0.34; 95% CI, 0.22-0.53). OR (95% CI) of low HDL-C (<50 mg/dL) and high triglyceride (TG; > or = 150 mg/dL) category was 2.20 (1.32-3.67) on estrogen receptor-negative and progesterone receptor-negative breast cancer compared with high HDL-C (> or = 50 mg/dL) and low TG (<150 mg/dL) category. This study suggests that higher level of HDL-C may reduce breast cancer risk among premenopausal women. Estrogen receptor-negative and progesterone receptor-negative breast cancer was associated with dyslipidemia, which implicates that association among HDL-C, TG, and breast cancer may be modified by receptor status. | en |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | en |
dc.subject | Breast Neoplasms/*blood/epidemiology | en |
dc.subject | Case-Control Studies | en |
dc.subject | Cholesterol, HDL/*blood | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Logistic Models | en |
dc.subject | Menopause/*blood | en |
dc.subject | Middle Aged | en |
dc.subject | Questionnaires | en |
dc.subject | Receptors, Estrogen/*blood | en |
dc.subject | Receptors, Progesterone/*blood | en |
dc.subject | Risk Factors | en |
dc.subject | Body Mass Index | - |
dc.title | Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김연주 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.contributor.AlternativeAuthor | 하은희 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-08-0133 | - |
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